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    Peptidase family C54 protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825165, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Peptidase family C54 protein
    Primary source
    TAIR:AT3G59950
    Locus tag
    AT3G59950
    See related
    Araport:AT3G59950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (22144280..22147712, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene defensin-like protein Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene histone-lysine N-methyltransferase ASHH4 Neighboring gene methylenetetrahydrofolate reductase 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ATG4 cysteine proteases specificity toward ATG8 substrates. Park E, et al. Autophagy, 2014 May. PMID 24658121, Free PMC Article
    2. Calmodulin-related CML24 interacts with ATG4b and affects autophagy progression in Arabidopsis. Tsai YC, et al. Plant J, 2013 Jan. PMID 23039100
    3. Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Yoshimoto K, et al. Plant Cell, 2004 Nov. PMID 15494556, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results support the conclusion that CML24 affects autophagy progression through interactions with ATG4.
      Title: Calmodulin-related CML24 interacts with ATG4b and affects autophagy progression in Arabidopsis.
    2. AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. [ATG4b]
      Title: Arabidopsis ATG4 cysteine proteases specificity toward ATG8 substrates.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001125387.1
    NM_001340006.1
    NM_001340007.1
    NM_115858.6
    NM_180391.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-phosphatidylethanolamide deconjugating activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase family C54 protein
    NP_001118859.1
    • Peptidase family C54 protein; FUNCTIONS IN: peptidase activity; INVOLVED IN: autophagy; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C54 (InterPro:IPR005078); BEST Arabidopsis thaliana protein match is: Peptidase family C54 protein (TAIR:AT2G44140.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_191554.1
    • Peptidase family C54 protein; FUNCTIONS IN: peptidase activity; INVOLVED IN: autophagy; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C54 (InterPro:IPR005078); BEST Arabidopsis thaliana protein match is: Peptidase family C54 protein (TAIR:AT2G44140.1); Has 844 Blast hits to 806 proteins in 218 species: Archae - 0; Bacteria - 0; Metazoa - 426; Fungi - 182; Plants - 81; Viruses - 0; Other Eukaryotes - 155 (source: NCBI BLink).
    NP_850722.3
    • Peptidase family C54 protein; FUNCTIONS IN: peptidase activity; INVOLVED IN: autophagy; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C54 (InterPro:IPR005078); BEST Arabidopsis thaliana protein match is: Peptidase family C54 protein (TAIR:AT2G44140.1); Has 737 Blast hits to 737 proteins in 201 species: Archae - 0; Bacteria - 0; Metazoa - 397; Fungi - 164; Plants - 72; Viruses - 0; Other Eukaryotes - 104 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22144280..22147712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180391.4 → NP_850722.3  Peptidase family C54 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850722.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J9I3
      Conserved Domains (1) summary
      pfam03416
      Location:140 → 299
      Peptidase_C54; Peptidase family C54

    2. NM_115858.6 → NP_191554.1  Peptidase family C54 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570T6, Q9M1Y0
      UniProtKB/TrEMBL
      A0A178VJJ3, A0A5S9XMD2
      Conserved Domains (1) summary
      pfam03416
      Location:140 → 425
      Peptidase_C54; Peptidase family C54

    3. NM_001340006.1 → NP_001325933.1  Peptidase family C54 protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LMQ9, A0A7G2EWD4

    4. NM_001340007.1 → NP_001325932.1  Peptidase family C54 protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LMQ8, A0A5S9XMD2

    5. NM_001125387.1 → NP_001118859.1  Peptidase family C54 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1Y0
      Conserved Domains (1) summary
      pfam03416
      Location:54 → 213
      Peptidase_C54; Peptidase family C54
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1Y0.1

    Gene LinkOut

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