Tacc3 transforming, acidic coiled-coil containing protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tacc3provided by MGI
Official Full Name: transforming, acidic coiled-coil containing protein 3provided by MGI
Primary source: MGI:MGI:1341163
See related: Ensembl:ENSMUSG00000037313 AllianceGenome:MGI:1341163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aint; Eric1
Summary: Enables protein domain specific binding activity. Acts upstream of or within several processes, including astral microtubule organization; cytoplasmic sequestering of transcription factor; and nervous system development. Located in centrosome and cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 34.6), liver E14 (RPKM 25.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.83 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (33814808..33836331)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (33658128..33672203)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
Title: Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
Aurora kinase A is essential for meiosis in mouse oocytes.
Title: Aurora kinase A is essential for meiosis in mouse oocytes.
Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation.
Title: Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation.
Tacc3 is required for the proper mitosis of Apc-deficient ISCs, and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival.
Title: Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.
Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.
Title: The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
Title: Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
Title: DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
Title: Disruption of Tacc3 function leads to in vivo tumor regression.
Tacc3 is a negative regulator of the Notch signaling pathway.
Title: Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
Title: TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tacc3 (e-PCR), detects polymorphism
- UniSTS:498283

Tacc3 (e-PCR), detects polymorphism
- UniSTS:144538

PMC125348P1 (e-PCR)
- UniSTS:270491

C86661 (e-PCR)
- UniSTS:207771

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within astral microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasmic sequestering of transcription factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase/anaphase transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization involved in mitosis	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of microtubule-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transforming acidic coiled-coil-containing protein 3

Names: ARNT-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040435.4 → NP_001035525.1 transforming acidic coiled-coil-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_001035525.1

Status: VALIDATED

Source sequence(s)

AC162898

Consensus CDS

CCDS39065.1

UniProtKB/TrEMBL

Q6NV52, Q9JIQ5

Related

ENSMUSP00000110069.4, ENSMUST00000114426.10

Conserved Domains (2) summary

pfam05010
Location:428 → 624

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl03075
Location:426 → 580

GrpE; nucleotide exchange factor GrpE
NM_001310541.2 → NP_001297470.1 transforming acidic coiled-coil-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_001297470.1

Status: VALIDATED

Source sequence(s)

AC162898

Consensus CDS

CCDS80258.1

UniProtKB/TrEMBL

Q99LH8, Q9JIQ5

Related

ENSMUSP00000074394.7, ENSMUST00000074849.13

Conserved Domains (2) summary

PRK10811
Location:144 → 294

rne; ribonuclease E; Reviewed

pfam05010
Location:435 → 631

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_001405350.1 → NP_001392279.1 transforming acidic coiled-coil-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5
NM_001405351.1 → NP_001392280.1 transforming acidic coiled-coil-containing protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5
NM_001405352.1 → NP_001392281.1 transforming acidic coiled-coil-containing protein 3 isoform 5

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5
NM_001405353.1 → NP_001392282.1 transforming acidic coiled-coil-containing protein 3 isoform 6

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5
NM_001405354.1 → NP_001392283.1 transforming acidic coiled-coil-containing protein 3 isoform 7

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5
NM_001405355.1 → NP_001392284.1 transforming acidic coiled-coil-containing protein 3 isoform 8

Status: VALIDATED

Source sequence(s)

AC162898
NM_001405356.1 → NP_001392285.1 transforming acidic coiled-coil-containing protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q6NV52, Q9JIQ5

Related

ENSMUSP00000078491.5, ENSMUST00000079534.11
NM_001405357.1 → NP_001392286.1 transforming acidic coiled-coil-containing protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q6NV52, Q9JIQ5
NM_001405358.1 → NP_001392287.1 transforming acidic coiled-coil-containing protein 3 isoform 9

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5
NM_001405360.1 → NP_001392289.1 transforming acidic coiled-coil-containing protein 3 isoform 9

Status: VALIDATED

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q9JIQ5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

33814808..33836331

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254350.2 → XP_030110210.1 transforming acidic coiled-coil-containing protein 3 isoform X6

UniProtKB/TrEMBL

Q9JIQ5

Conserved Domains (2) summary

PRK10811
Location:144 → 294

rne; ribonuclease E; Reviewed

pfam05010
Location:428 → 569

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_030254352.2 → XP_030110212.1 transforming acidic coiled-coil-containing protein 3 isoform X9

Conserved Domains (2) summary

PRK10811
Location:71 → 221

rne; ribonuclease E; Reviewed

pfam05010
Location:355 → 496

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_030254349.2 → XP_030110209.1 transforming acidic coiled-coil-containing protein 3 isoform X3

UniProtKB/TrEMBL

Q9JIQ5

Conserved Domains (3) summary

PRK10263
Location:23 → 274

PRK10263; DNA translocase FtsK; Provisional

PRK10811
Location:160 → 310

rne; ribonuclease E; Reviewed

pfam05010
Location:444 → 626

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_006503835.5 → XP_006503898.1 transforming acidic coiled-coil-containing protein 3 isoform X7

UniProtKB/TrEMBL

Q9JIQ5

Conserved Domains (2) summary

PRK10811
Location:71 → 221

rne; ribonuclease E; Reviewed

pfam05010
Location:362 → 558

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_011240716.4 → XP_011239018.1 transforming acidic coiled-coil-containing protein 3 isoform X4

UniProtKB/TrEMBL

Q9JIQ5

Conserved Domains (3) summary

PRK10263
Location:23 → 274

PRK10263; DNA translocase FtsK; Provisional

PRK10811
Location:160 → 310

rne; ribonuclease E; Reviewed

pfam05010
Location:451 → 592

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_011240715.1 → XP_011239017.1 transforming acidic coiled-coil-containing protein 3 isoform X1

UniProtKB/TrEMBL

Q9JIQ5

Conserved Domains (3) summary

PRK10263
Location:23 → 274

PRK10263; DNA translocase FtsK; Provisional

PRK10811
Location:160 → 310

rne; ribonuclease E; Reviewed

pfam05010
Location:444 → 640

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_036164983.1 → XP_036020876.1 transforming acidic coiled-coil-containing protein 3 isoform X5

UniProtKB/TrEMBL

Q9JIQ5

Conserved Domains (3) summary

PRK10263
Location:23 → 274

PRK10263; DNA translocase FtsK; Provisional

PRK10811
Location:160 → 310

rne; ribonuclease E; Reviewed

pfam05010
Location:444 → 583

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_006503832.4 → XP_006503895.1 transforming acidic coiled-coil-containing protein 3 isoform X2

See identical proteins and their annotated locations for XP_006503895.1

UniProtKB/TrEMBL

Q99LH8, Q9JIQ5

Conserved Domains (2) summary

PRK10811
Location:144 → 294

rne; ribonuclease E; Reviewed

pfam05010
Location:435 → 631

TACC; Transforming acidic coiled-coil-containing protein (TACC)

RNA

XR_868281.4 RNA Sequence
XR_003955613.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_011524.3: Suppressed sequence

Description

NM_011524.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.