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    Taf8 TATA-box binding protein associated factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 63856, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taf8provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 8provided by MGI
    Primary source
    MGI:MGI:1926879
    See related
    Ensembl:ENSMUSG00000023980 AllianceGenome:MGI:1926879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tbn
    Summary
    Predicted to enable protein heterodimerization activity. Acts upstream of or within inner cell mass cell proliferation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in several structures, including Harderian gland; brain; early conceptus; genitourinary system; and tongue. Orthologous to human TAF8 (TATA-box binding protein associated factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.5), CNS E11.5 (RPKM 9.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taf8 in Genome Data Viewer
    Location:
    17 C; 17 23.33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47794289..47813216, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47483364..47502321, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene guanylate cyclase activator 1a (retina) Neighboring gene Morf4 family associated protein 1 pseudogene Neighboring gene ciliary microtubule inner protein 3 Neighboring gene expressed sequence AI661453 Neighboring gene STARR-seq mESC enhancer starr_42703 Neighboring gene STARR-positive B cell enhancer ABC_E9168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47641447-47641630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47641910-47642097 Neighboring gene STARR-positive B cell enhancer ABC_E5616 Neighboring gene STARR-seq mESC enhancer starr_42710 Neighboring gene STARR-positive B cell enhancer ABC_E10958 Neighboring gene VISTA enhancer mm1691 Neighboring gene cyclin D3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47668330-47668738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47679075-47679320 Neighboring gene predicted gene, 41590 Neighboring gene STARR-seq mESC enhancer starr_42717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47732923-47733032 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene bystin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription open complex formation PubMed 
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in cell differentiation  
    acts_upstream_of_or_within inner cell mass cell proliferation PubMed 
    involved_in mRNA transcription by RNA polymerase II  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in maintenance of protein location in nucleus  
    involved_in maintenance of protein location in nucleus  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    acts_upstream_of_or_within regulation of fat cell differentiation PubMed 
    involved_in transcription initiation at RNA polymerase II promoter  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    part_of transcription factor TFIID complex  
    part_of transcription factor TFIID complex PubMed 
    part_of transcription factor TFIID complex  

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 8
    Names
    TBP-associated factor 8
    protein taube nuss

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356290.1NP_001343219.1  transcription initiation factor TFIID subunit 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139214, AK162110
      Consensus CDS
      CCDS89109.1
      Related
      ENSMUSP00000156668.2, ENSMUST00000233174.2
      Conserved Domains (2) summary
      cd08049
      Location:142195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27104
      Bromo_TP; Bromodomain associated
    2. NM_001410186.1NP_001397115.1  transcription initiation factor TFIID subunit 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139214
    3. NM_001410187.1NP_001397116.1  transcription initiation factor TFIID subunit 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC139214
    4. NM_001410188.1NP_001397117.1  transcription initiation factor TFIID subunit 8 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC139214
      Related
      ENSMUSP00000156629.2, ENSMUST00000233121.2
    5. NM_001410189.1NP_001397118.1  transcription initiation factor TFIID subunit 8 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC139214
    6. NM_001410190.1NP_001397119.1  transcription initiation factor TFIID subunit 8 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC139214
    7. NM_001410191.1NP_001397120.1  transcription initiation factor TFIID subunit 8 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC139214
    8. NM_022015.5NP_071298.1  transcription initiation factor TFIID subunit 8 isoform 1

      See identical proteins and their annotated locations for NP_071298.1

      Status: VALIDATED

      Source sequence(s)
      AC139214
      Consensus CDS
      CCDS37642.1
      UniProtKB/Swiss-Prot
      Q3TSE4, Q6PES8, Q8C382, Q8C664, Q8C7L7, Q9EQH4
      Related
      ENSMUSP00000063201.3, ENSMUST00000067103.4
      Conserved Domains (2) summary
      cd08049
      Location:142195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27104
      Bromo_TP; Bromodomain associated

    RNA

    1. NR_176962.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139214
    2. NR_176963.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139214

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47794289..47813216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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