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    Ppp6r3 protein phosphatase 6, regulatory subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 52036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp6r3provided by MGI
    Official Full Name
    protein phosphatase 6, regulatory subunit 3provided by MGI
    Primary source
    MGI:MGI:1921807
    See related
    Ensembl:ENSMUSG00000024908 AllianceGenome:MGI:1921807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sapl; Pp6r3; Ppcs3; Saps3; Pptcs3; mKIAA1558; D19Bwg1430e; D19Ertd703e; 4930528G08Rik; 9130026N02Rik
    Summary
    Predicted to enable protein phosphatase binding activity and protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in cerebellum Purkinje cell layer; cerebellum granule cell layer; and neocortex. Orthologous to human PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 26.1), thymus adult (RPKM 20.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp6r3 in Genome Data Viewer
    Location:
    19 A; 19 3.21 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3504928..3626191, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3454928..3576033, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene testis expressed metallothionein like Neighboring gene galanin and GMAP prepropeptide Neighboring gene STARR-seq mESC enhancer starr_45317 Neighboring gene predicted gene, 23940 Neighboring gene STARR-seq mESC enhancer starr_45318 Neighboring gene STARR-positive B cell enhancer ABC_E401 Neighboring gene UTP3, small subunit processome component, homolog pseudogene Neighboring gene low density lipoprotein receptor-related protein 5 Neighboring gene VISTA enhancer mm1719 Neighboring gene predicted gene, 36672 Neighboring gene predicted gene, 36608

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. Al-Barghouthi BM, et al. Elife, 2022 Nov 23. PMID 36416764, Free PMC Article
    2. SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice. Yang Y, et al. Nat Commun, 2023 Mar 13. PMID 36914647, Free PMC Article
    3. Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Saijoh Y, et al. Genes Cells, 1996 Feb. PMID 9140067
    4. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson B, et al. J Biol Chem, 2006 Aug 11. PMID 16769727
    5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice.
      Title: SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 3
    Names
    SAPS domain family, member 3
    pluripotent cell-specific 3
    sporulation-induced transcript 4-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164159.1 → NP_001157631.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3

      See identical proteins and their annotated locations for NP_001157631.1

      Status: VALIDATED

      Source sequence(s)
      AK035236, AV456025, BB661794, BP760563, BU612294, BY720838, CF537891, CK619000
      Consensus CDS
      CCDS50340.1
      UniProtKB/Swiss-Prot
      Q922D4
      Related
      ENSMUSP00000131084.2, ENSMUST00000172362.3
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      cl00478
      Location:688 → 820
      LGT; Prolipoprotein diacylglyceryl transferase

    2. NM_001360429.1 → NP_001347358.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117797, BP760563
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:624 → 877
      DUF4775; Domain of unknown function (DUF4775)

    3. NM_001360430.1 → NP_001347359.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117797, BP760563
      Consensus CDS
      CCDS50340.1
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      cl00478
      Location:688 → 820
      LGT; Prolipoprotein diacylglyceryl transferase

    4. NM_028999.1 → NP_083275.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_083275.1

      Status: VALIDATED

      Source sequence(s)
      AK035236, AV456025, BB661794, BP760563, CF537891, CF727136, CK619000
      Consensus CDS
      CCDS50341.1
      UniProtKB/TrEMBL
      G5E8R4
      Related
      ENSMUSP00000109630.3, ENSMUST00000113997.9
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:624 → 871
      DUF4775; Domain of unknown function (DUF4775)

    5. NM_029456.2 → NP_083732.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_083732.1

      Status: VALIDATED

      Source sequence(s)
      AK035236, AV456025, BB661794, BP760563, CF537891, CK619000
      Consensus CDS
      CCDS29397.1
      UniProtKB/Swiss-Prot
      Q6ZPM9, Q8BTW6, Q922D4, Q9D2X9
      Related
      ENSMUSP00000025846.9, ENSMUST00000025846.16
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      3504928..3626191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318250.3 → XP_017173739.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    2. XM_017318249.3 → XP_017173738.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:589 → 836
      DUF4775; Domain of unknown function (DUF4775)

    3. XM_006531794.3 → XP_006531857.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:589 → 842
      DUF4775; Domain of unknown function (DUF4775)

    4. XM_017318248.3 → XP_017173737.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:607 → 854
      DUF4775; Domain of unknown function (DUF4775)

    5. XM_011248641.3 → XP_011246943.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:607 → 860
      DUF4775; Domain of unknown function (DUF4775)

    6. XM_006531792.3 → XP_006531855.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:618 → 865
      DUF4775; Domain of unknown function (DUF4775)

    7. XM_011248640.3 → XP_011246942.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:618 → 871
      DUF4775; Domain of unknown function (DUF4775)

    8. XM_011248642.4 → XP_011246944.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    9. XM_036161629.1 → XP_036017522.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    10. XM_036161624.1 → XP_036017517.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    11. XM_036161626.1 → XP_036017519.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

      UniProtKB/Swiss-Prot
      Q6ZPM9, Q8BTW6, Q922D4, Q9D2X9
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    12. XM_030250988.2 → XP_030106848.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

      UniProtKB/TrEMBL
      G5E8R4
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:624 → 871
      DUF4775; Domain of unknown function (DUF4775)

    13. XM_030250986.2 → XP_030106846.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:624 → 877
      DUF4775; Domain of unknown function (DUF4775)

    14. XM_030250987.2 → XP_030106847.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein
      pfam16001
      Location:624 → 877
      DUF4775; Domain of unknown function (DUF4775)

    15. XM_036161627.1 → XP_036017520.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

      Conserved Domains (1) summary
      pfam04499
      Location:117 → 467
      SAPS; SIT4 phosphatase-associated protein

    16. XM_036161625.1 → XP_036017518.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    17. XM_036161628.1 → XP_036017521.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

      Conserved Domains (1) summary
      pfam04499
      Location:117 → 467
      SAPS; SIT4 phosphatase-associated protein

    18. XM_006531797.5 → XP_006531860.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X13

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    RNA

    1. XR_001782603.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922D4.1 GenPept UniProtKB/Swiss-Prot:Q922D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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