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    Slc5a3 solute carrier family 5 (inositol transporters), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 53881, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc5a3provided by MGI
    Official Full Name
    solute carrier family 5 (inositol transporters), member 3provided by MGI
    Primary source
    MGI:MGI:1858226
    See related
    Ensembl:ENSMUSG00000089774 AllianceGenome:MGI:1858226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smit1
    Summary
    Predicted to enable potassium channel regulator activity; solute:sodium symporter activity; and transmembrane transporter binding activity. Involved in regulation of transporter activity. Acts upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of reactive oxygen species biosynthetic process. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SLC5A3 (solute carrier family 5 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 7.8), genital fat pad adult (RPKM 7.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Slc5a3 in Genome Data Viewer
    Location:
    16 C4; 16 53.44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91855210..91884361)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (92058322..92087473)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41494 Neighboring gene predicted gene, 18020 Neighboring gene predicted gene, 23210 Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene STARR-seq mESC enhancer starr_41496 Neighboring gene predicted gene, 41496 Neighboring gene STARR-seq mESC enhancer starr_41498 Neighboring gene STARR-seq mESC enhancer starr_41500 Neighboring gene predicted gene, 41495 Neighboring gene STARR-seq mESC enhancer starr_41501 Neighboring gene STARR-seq mESC enhancer starr_41503 Neighboring gene STARR-seq mESC enhancer starr_41504 Neighboring gene predicted gene, 29880

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myo-inositol:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium/myo-inositol cotransporter
    Names
    Na(+)/myo-inositol cotransporter
    sodium myo-inositol transporter 1
    solute carrier family 5, member 3
    solute carrier family 5, member alpha 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017391.3NP_059087.2  sodium/myo-inositol cotransporter

      See identical proteins and their annotated locations for NP_059087.2

      Status: VALIDATED

      Source sequence(s)
      AC144408, AK144718, BF318171
      Consensus CDS
      CCDS37403.1
      UniProtKB/Swiss-Prot
      B2RU60, Q9JKZ2
      Related
      ENSMUSP00000109608.3, ENSMUST00000113975.3
      Conserved Domains (1) summary
      cd11491
      Location:9718
      SLC5sbd_SMIT; Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91855210..91884361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)