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    Ist1 increased sodium tolerance 1 homolog (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 71955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ist1provided by MGI
    Official Full Name
    increased sodium tolerance 1 homolog (yeast)provided by MGI
    Primary source
    MGI:MGI:1919205
    See related
    Ensembl:ENSMUSG00000031729 AllianceGenome:MGI:1919205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHMP8; mKIAA0174; 2400003C14Rik
    Summary
    Predicted to enable MIT domain binding activity and identical protein binding activity. Acts upstream of or within positive regulation of collateral sprouting. Predicted to be located in several cellular components, including Flemming body; endoplasmic reticulum-Golgi intermediate compartment; and extracellular exosome. Is expressed in several structures, including branchial arch; limb bud; nervous system; sensory organ; and tooth. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 40.7), CNS E18 (RPKM 40.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ist1 in Genome Data Viewer
    Location:
    8 D3; 8 57.18 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110397953..110419929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109671321..109693297, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39247 Neighboring gene dihydroorotate dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726 Neighboring gene polycystic kidney disease 1 like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3805 Neighboring gene zinc finger protein 821 Neighboring gene predicted gene, 53453 Neighboring gene ataxin 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy. Tang Q, et al. J Neurochem, 2024 Jul. PMID 38348636
    2. Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Renvoisé B, et al. Hum Mol Genet, 2012 Aug 15. PMID 22619377, Free PMC Article
    3. Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. Hanson PI, et al. J Cell Biol, 2008 Jan 28. PMID 18209100, Free PMC Article
    4. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. Feng Q, et al. Autophagy, 2020 Apr. PMID 31223056, Free PMC Article
    5. Identification of tooth-specific downstream targets of Runx2. Gaikwad JS, et al. Gene, 2001 Nov 14. PMID 11722849

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy.
      Title: Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MIT domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MIT domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of collateral sprouting IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoskeleton-dependent cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbody abscission IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of collateral sprouting IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral capsid secondary envelopment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IST1 homolog
    Names
    charged multivesicular body protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361562.1 → NP_001348491.1  IST1 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC125162
      UniProtKB/TrEMBL
      Q8BHC2
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 176
      Ist1; Regulator of Vps4 activity in the MVB pathway

    2. NM_028018.2 → NP_082294.1  IST1 homolog isoform 1

      See identical proteins and their annotated locations for NP_082294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK010262, BE947178, BY160969
      Consensus CDS
      CCDS22655.1
      UniProtKB/Swiss-Prot
      Q80U68, Q9CX00
      Related
      ENSMUSP00000034164.5, ENSMUST00000034164.6
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 176
      Ist1; Regulator of Vps4 activity in the MVB pathway

    RNA

    1. NR_155034.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC125162

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110397953..110419929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154300.1 → XP_036010193.1  IST1 homolog isoform X1

      Conserved Domains (1) summary
      pfam03398
      Location:20 → 166
      Ist1; Regulator of Vps4 activity in the MVB pathway

    2. XM_017312971.3 → XP_017168460.1  IST1 homolog isoform X2

      Conserved Domains (1) summary
      pfam03398
      Location:1 → 108
      Ist1; Regulator of Vps4 activity in the MVB pathway

    RNA

    1. XR_003947337.2 RNA Sequence

      Related
      ENSMUST00000212973.2

    2. XR_001778470.2 RNA Sequence

    3. XR_001778468.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CX00.1 GenPept UniProtKB/Swiss-Prot:Q9CX00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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