Psg17 pregnancy specific beta-1-glycoprotein 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psg17provided by MGI
Official Full Name: pregnancy specific beta-1-glycoprotein 17provided by MGI
Primary source: MGI:MGI:1347250
See related: Ensembl:ENSMUSG00000004540 AllianceGenome:MGI:1347250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cea2; Cea-2; mmCGM5
Summary: Enables heparan sulfate proteoglycan binding activity. Acts upstream of or within immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including large intestine; liver; placenta; spleen; and spongiotrophoblast. Orthologous to human CEACAM7 (CEA cell adhesion molecule 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 44.6) See more
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Genomic context

Location:: 7 A3; 7 9.33 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18547862..18555516, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (18813937..18821591, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9-binding partner, was significantly decreased in GIP receptor-knockout (Gipr-/-) testes.
Title: Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice.
murine PSG17, like human PSG1, binds to the GAG chains on cell surface proteoglycans.
Title: Characterization of receptors for murine pregnancy specific glycoproteins 17 and 23.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Psg17 (e-PCR), detects polymorphism
- UniSTS:259518

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female pregnancy	TAS Traceable Author Statement more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pregnancy specific glycoprotein 17

Names: carcinoembryonic antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007677.2 → NP_031703.1 pregnancy specific glycoprotein 17 precursor

See identical proteins and their annotated locations for NP_031703.1

Status: VALIDATED

Source sequence(s)

BC100345, CN703708

Consensus CDS

CCDS20878.1

UniProtKB/TrEMBL

Q62056

Related

ENSMUSP00000004655.8, ENSMUST00000004655.8

Conserved Domains (3) summary

cd05774
Location:156 → 260

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00408
Location:400 → 461

IGc2; Immunoglobulin C-2 Type

smart00410
Location:280 → 380

IG_like; Immunoglobulin like