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    Ccl25 C-C motif chemokine ligand 25 [ Mus musculus (house mouse) ]

    Gene ID: 20300, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccl25provided by MGI
    Official Full Name
    C-C motif chemokine ligand 25provided by MGI
    Primary source
    MGI:MGI:1099448
    See related
    Ensembl:ENSMUSG00000023235 AllianceGenome:MGI:1099448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TECK; CKb15; Scya25; A130072A22Rik
    Summary
    Enables chemokine activity. Acts upstream of or within chemotaxis; leukocyte migration; and lymphoid lineage cell migration. Predicted to be active in extracellular space. Is expressed in 3rd branchial pouch; central nervous system; hemolymphoid system; retina; and thymus/parathyroid primordium. Orthologous to human CCL25 (C-C motif chemokine ligand 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 91.4), thymus adult (RPKM 40.0) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccl25 in Genome Data Viewer
    Location:
    8 A1.1; 8 2.01 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4375207..4410020)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4325205..4360020)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4988 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene ELAV like RNA binding protein 1 Neighboring gene predicted gene, 50600 Neighboring gene predicted gene 7434 Neighboring gene peptidylprolyl isomerase A pseudogene 8_36.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR10 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lymphoid lineage cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 25
    Names
    chemokine (C-C motif) ligand 25
    small inducible chemokine 25
    small inducible cytokine A25
    thymus-expressed chemokine

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009138.3NP_033164.1  C-C motif chemokine 25 precursor

      See identical proteins and their annotated locations for NP_033164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK131875, AK134138, DQ158256
      Consensus CDS
      CCDS22085.1
      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Related
      ENSMUSP00000024004.8, ENSMUST00000024004.9
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

    RNA

    1. NR_033527.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and includes two alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK132700, DQ158256
      Related
      ENSMUST00000155797.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4375207..4410020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508736.5XP_006508799.1  C-C motif chemokine 25 isoform X2

      UniProtKB/TrEMBL
      D3YWJ1
      Related
      ENSMUSP00000120719.3, ENSMUST00000127460.8
      Conserved Domains (1) summary
      cd01119
      Location:112173
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    2. XM_030243364.1XP_030099224.1  C-C motif chemokine 25 isoform X4

      Conserved Domains (1) summary
      cd01119
      Location:81142
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    3. XM_036153845.1XP_036009738.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    4. XM_036153847.1XP_036009740.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    5. XM_036153840.1XP_036009733.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    6. XM_036153843.1XP_036009736.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    7. XM_036153848.1XP_036009741.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    8. XM_036153841.1XP_036009734.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    9. XM_036153846.1XP_036009739.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    10. XM_011242043.3XP_011240345.3  C-C motif chemokine 25 isoform X1

      Conserved Domains (1) summary
      cd01119
      Location:117178
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    11. XM_011242044.4XP_011240346.3  C-C motif chemokine 25 isoform X3

      Conserved Domains (1) summary
      cd01119
      Location:86147
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    12. XM_011242045.3XP_011240347.1  C-C motif chemokine 25 isoform X5

      Conserved Domains (1) summary
      cd01119
      Location:45106
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    13. XM_036153844.1XP_036009737.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    14. XM_036153842.1XP_036009735.1  C-C motif chemokine 25 isoform X6

      UniProtKB/Swiss-Prot
      O35903, Q9QYY6
      UniProtKB/TrEMBL
      Q3V2F3
      Conserved Domains (1) summary
      cd01119
      Location:2889
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...