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    PIMT1 protein-l-isoaspartate methyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823991, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIMT1
    Official Full Name
    protein-l-isoaspartate methyltransferase 1
    Primary source
    TAIR:AT3G48330
    Locus tag
    AT3G48330
    See related
    Araport:AT3G48330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana protein-l-isoaspartate methyltransferase 1; ATPIMT1; protein-l-isoaspartate methyltransferase 1
    Summary
    Encodes protein-L-isoaspartate methyltransferase. Important for maintaining viability as the seed ages. Involved in germination.
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    Genomic context

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    See PIMT1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (17892738..17894162, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 71, subfamily A, polypeptide 22 Neighboring gene cytochrome P450, family 71, subfamily A, polypeptide 21 Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene Cysteine proteinases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein repair L-isoaspartyl methyltransferase 1 is involved in both seed longevity and germination vigor in Arabidopsis. Ogé L, et al. Plant Cell, 2008 Nov. PMID 19011119, Free PMC Article
    2. Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures. Villa ST, et al. Physiol Plant, 2006 Dec. PMID 21076691, Free PMC Article
    3. Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning. Chen T, et al. J Biol Chem, 2010 Nov 26. PMID 20870712, Free PMC Article
    4. A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus. Xu Q, et al. Plant Physiol, 2004 Sep. PMID 15347786, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 17 PIMT target proteins all contain at least one susceptible Asp or Asn residue.
      Title: Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning.
    2. PIMT1 overaccumulation reduced the accumulation of L-isoaspartyl residues in seed proteins and increased both seed longevity and germination vigor.
      Title: Protein repair L-isoaspartyl methyltransferase 1 is involved in both seed longevity and germination vigor in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001339361.1
    NM_001339362.1
    NM_148859.4
    NM_180682.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    protein-l-isoaspartate methyltransferase 1
    NP_680112.2
    • protein-l-isoaspartate methyltransferase 1 (PIMT1); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process, response to salt stress, aging, response to abscisic acid stimulus, seed germination; LOCATED IN: cellular_component unknown; EXPRESSED IN: seedling, seed; EXPRESSED DURING: dry seed stage; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 2 (TAIR:AT5G50240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_851013.2
    • protein-l-isoaspartate methyltransferase 1 (PIMT1); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process, response to salt stress, aging, response to abscisic acid stimulus, seed germination; LOCATED IN: cellular_component unknown; EXPRESSED IN: seedling, seed; EXPRESSED DURING: dry seed stage; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 2 (TAIR:AT5G50240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17892738..17894162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_148859.4 → NP_680112.2  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_680112.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JQ02, Q42539, Q9STL3
      UniProtKB/TrEMBL
      A0A178VNY7
      Conserved Domains (2) summary
      pfam01135
      Location:11 → 220
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:12 → 225
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_180682.4 → NP_851013.2  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851013.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JQ02, Q42539, Q9STL3
      UniProtKB/TrEMBL
      A0A178VNY7
      Conserved Domains (2) summary
      pfam01135
      Location:11 → 220
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:12 → 225
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001339361.1 → NP_001326364.1  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VNY7, A0A1I9LP19

    4. NM_001339362.1 → NP_001326363.1  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LP18, A0A654FDX5
      Conserved Domains (1) summary
      pfam01135
      Location:64 → 273
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42539.3

    Gene LinkOut

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