XDH1 xanthine dehydrogenase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: XDH1
Official Full Name: xanthine dehydrogenase 1
Primary source: TAIR:AT4G34890
Locus tag: AT4G34890
See related: Araport:AT4G34890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATXDH1; F11I11.130; F11I11_130; xanthine dehydrogenase 1; XANTHINE DEHYDROGENASE 1
Summary: Encodes a xanthine dehydrogenase, involved in purine catabolism. Ubiquitously expressed, but the transcript level is altered during aging, senescence, salt and cold stress, ABA treatment, and dark treatment. RNAi lines that suppress both XDH1 and XDH2 produce small plants with reduced fertility and accelerated leaf senescence. Role in drought tolerance.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The Atxdh1 Mutation confers lower organic nitrogen and soluble protein levels but higher RNA than in wild-type old leaves grown under nitrogen deficiency
Title: Early Senescence in Older Leaves of Low Nitrate-Grown Atxdh1 Uncovers a Role for Purine Catabolism in N Supply.
Fully functional XDH and purine metabolism plays a role in the Arabidopsis drought acclimatization.
Title: RNA interference-mediated suppression of xanthine dehydrogenase reveals the role of purine metabolism in drought tolerance in Arabidopsis.
AtXDH1 is capable of oxidizing NADH with concomitant formation of NAD(+) and superoxide.
Title: Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a potent producer of superoxide anions via its NADH oxidase activity.
RNA interference was used to generate transgenic lines of this species in which AtXDH1 and AtXDH2, the two paralogous genes for XDH in this plant, were silenced simultaneously.
Title: The RNAi-mediated silencing of xanthine dehydrogenase impairs growth and fertility and accelerates leaf senescence in transgenic Arabidopsis plants.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_119655.4

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables xanthine dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within purine nucleobase catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within purine nucleobase catabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xanthine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed

NP_195215.2

xanthine dehydrogenase 1 (XDH1); CONTAINS InterPro DOMAIN/s: Aldehyde oxidase/xanthine dehydrogenase (InterPro:IPR016208), Ferredoxin (InterPro:IPR001041), Molybdopterin dehydrogenase, FAD-binding (InterPro:IPR002346), [2Fe-2S]-binding (InterPro:IPR002888), FAD-binding, type 2, subdomain 1 (InterPro:IPR016167), FAD-binding, type 2 (InterPro:IPR016166), CO dehydrogenase flavoprotein, C-terminal (InterPro:IPR005107), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 (InterPro:IPR016169), Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (InterPro:IPR000674), Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding (InterPro:IPR008274); BEST Arabidopsis thaliana protein match is: xanthine dehydrogenase 2 (TAIR:AT4G34900.1); Has 21952 Blast hits to 20911 proteins in 1336 species: Archae - 451; Bacteria - 13165; Metazoa - 1072; Fungi - 101; Plants - 265; Viruses - 0; Other Eukaryotes - 6898 (source: NCBI BLink).