PRR9 pseudo-response regulator 9 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PRR9
Official Full Name: pseudo-response regulator 9
Primary source: TAIR:AT2G46790
Locus tag: AT2G46790
See related: Araport:AT2G46790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: APRR9; Arabidopsis pseudo-response regulator 9; F19D11.7; pseudo-response regulator 9; TL1; TOC1-LIKE PROTEIN 1
Summary: Pseudo-response regulator PRR9. Involved in clock function. PRR7 and PRR9 are partially redundant essential components of a temperature-sensitive circadian system. CCA1 and LHY had a positive effect on PRR9. Interact with TOC1 in a yeast two-hybrid assay. Acts as transcriptional repressor of CCA1 and LHY.
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Genomic context

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See PRR9 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (19232607..19235179)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complex epistatic interactions between ELF3, PRR9, and PRR7 regulate the circadian clock and plant physiology.
Title: Complex epistatic interactions between ELF3, PRR9, and PRR7 regulate the circadian clock and plant physiology.
PRR9, a core circadian component, is a key regulator of leaf senescence via positive regulation of ORE1 through a feed-forward pathway involving posttranscriptional regulation by miR164 and direct transcriptional regulation.
Title: Circadian control of ORE1 by PRR9 positively regulates leaf senescence in Arabidopsis.
Transcriptional co-regulators PRR9, PRR7 and PRR5 inhibit morning loops LHY and CCA1 expression by binding to their promoters.
Title: A Bayesian approach for parameter estimation in the extended clock gene circuit of Arabidopsis thaliana.
PPR9 regulates the promoter activity of LWD1/2.
Title: LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive feedback regulatory loop in the Arabidopsis circadian clock.
Results reveal a role of PRR7 and PRR9 in regulating CCA1 and LHY activities in response to ambient temperature.
Title: The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation.
PRR9, PRR7, and PRR5 proteins are major transcriptional repressors of CCA1 and LHY and are thus essential for proper clock function.
Title: PSEUDO-RESPONSE REGULATORS 9, 7, and 5 are transcriptional repressors in the Arabidopsis circadian clock.
Data show that PRR9 polypeptides oscillate diurnally, and that they accumulate rapidly in response to light, and further suggest that the presence of PRR9 polypeptides is controlled through proteasome-mediated programmed degradation in the dark.
Title: Rhythmic and light-inducible appearance of clock-associated pseudo-response regulator protein PRR9 through programmed degradation in the dark in Arabidopsis thaliana.
The role of clock-associated genes PRR9, PRR7 and PRR5 are involved in activation of CONSTANS and CO-FLOWERING LOCUS T are reported.
Title: Arabidopsis clock-associated pseudo-response regulators PRR9, PRR7 and PRR5 coordinately and positively regulate flowering time through the canonical CONSTANS-dependent photoperiodic pathway.
single prr7-3 or prr9-1 mutants exhibit modest period lengthening, but the prr7-3 prr9-1 double mutant shows dramatic and more than additive period lengthening in the light and becomes arrhythmic in constant darkness
Title: PSEUDO-RESPONSE REGULATOR 7 and 9 are partially redundant genes essential for the temperature responsiveness of the Arabidopsis circadian clock.
The APRR9 promoter contains at least two distinctive and separable regulatory cis-elements: an "L element" responsible for the light-induced expression, followed by an "R element" necessary for the fundamental rhythmic expression of the gene.
Title: Molecular dissection of the promoter of the light-induced and circadian-controlled APRR9 gene encoding a clock-associated component of Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001337214.1

Supported by ESTs:

NM_130245.5

Supported by ESTs:

NM_201974.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphorelay response regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in cytokinin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within red or far-red light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of flower development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: pseudo-response regulator 9

NP_566085.1

pseudo-response regulator 9 (PRR9); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: CCT motif family protein (TAIR:AT2G46670.1); Has 67918 Blast hits to 66591 proteins in 3038 species: Archae - 212; Bacteria - 59069; Metazoa - 375; Fungi - 591; Plants - 3099; Viruses - 4; Other Eukaryotes - 4568 (source: NCBI BLink).

NP_973703.1

pseudo-response regulator 9 (PRR9); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: CCT motif family protein (TAIR:AT2G46670.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19232607..19235179

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001337213.1 → NP_001325092.1 pseudo-response regulator 9 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B243, Q683A6
NM_001337212.1 → NP_001325093.1 pseudo-response regulator 9 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VZH2, A0A1P8B286, A0A5S9X7N5

Conserved Domains (3) summary

COG5271
Location:163 → 401

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17582
Location:39 → 142

psREC_PRR; pseudo receiver domain of pseudo-response regulators

pfam06203
Location:417 → 438

CCT; CCT motif
NM_130245.5 → NP_566085.1 pseudo-response regulator 9 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566085.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81035, Q8L500, Q9LKL1

UniProtKB/TrEMBL

A0A178VZH2, A0A5S9X7N5, A0A654F2M7, Q56XM1

Conserved Domains (3) summary

COG5271
Location:163 → 401

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17582
Location:39 → 142

psREC_PRR; pseudo receiver domain of pseudo-response regulators

pfam06203
Location:417 → 458

CCT; CCT motif
NM_201974.3 → NP_973703.1 pseudo-response regulator 9 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973703.1

Status: REVIEWED

UniProtKB/TrEMBL

F4IJA1

Conserved Domains (2) summary

pfam06203
Location:300 → 341

CCT; CCT motif

cl19078
Location:1 → 38

REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
NM_001337214.1 → NP_001325091.1 pseudo-response regulator 9 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B243, Q683A6