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    NTRB NADPH-dependent thioredoxin reductase B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829698, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NTRB
    Official Full Name
    NADPH-dependent thioredoxin reductase B
    Primary source
    TAIR:AT4G35460
    Locus tag
    AT4G35460
    See related
    Araport:AT4G35460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNTRB; F15J1.30; F15J1_30; NADPH-DEPENDENT THIOREDOXIN REDUCTASE 1; NADPH-dependent thioredoxin reductase B; NTR1
    Summary
    NADPH-dependent thioredoxin reductase 1 (NTR1. Similar to E.coli NTR and has conserved NADPH binding domains.
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    Genomic context

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    See NTRB in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (16842174..16844359)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene chloride channel E Neighboring gene ankyrin repeat-containing protein 2 Neighboring gene plant intracellular ras group-related LRR 4 Neighboring gene uncharacterized protein Neighboring gene RING-H2 finger A3B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide is required for the auxin-induced activation of NADPH-dependent thioredoxin reductase and protein denitrosylation during root growth responses in arabidopsis. Correa-Aragunde N, et al. Ann Bot, 2015 Sep. PMID 26229066, Free PMC Article
    2. Arabidopsis thaliana NAPHP thioredoxin reductase. cDNA characterization and expression of the recombinant protein in Escherichia coli. Jacquot JP, et al. J Mol Biol, 1994 Jan 28. PMID 8308900
    3. AtNTRB is the major mitochondrial thioredoxin reductase in Arabidopsis thaliana. Reichheld JP, et al. FEBS Lett, 2005 Jan 17. PMID 15642341
    4. Inactivation of thioredoxin reductases reveals a complex interplay between thioredoxin and glutathione pathways in Arabidopsis development. Reichheld JP, et al. Plant Cell, 2007 Jun. PMID 17586656, Free PMC Article
    5. Identification and characterization of a mitochondrial thioredoxin system in plants. Laloi C, et al. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717467, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTR is involved in protein denitrosylation during auxin-mediated root development. As a high NO concentration induces NTR activity, a feedback mechanism to control massive and unregulated protein S-nitrosylation might operate in plant cells.
      Title: Nitric oxide is required for the auxin-induced activation of NADPH-dependent thioredoxin reductase and protein denitrosylation during root growth responses in arabidopsis.
    2. AtNTRB gene encodes two mRNAs and appeares to express the major mitochondrial thioredoxin reductases (AtNTRB).
      Title: AtNTRB is the major mitochondrial thioredoxin reductase in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_119711.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell redox homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular oxidant detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within seed development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    NADPH-dependent thioredoxin reductase B
    NP_195271.2
    • NADPH-dependent thioredoxin reductase B (NTRB); FUNCTIONS IN: thioredoxin-disulfide reductase activity; INVOLVED IN: pollen germination, thioredoxin biosynthetic process, cell growth, seed development, cell redox homeostasis; LOCATED IN: cytosol, mitochondrion, chloroplast envelope; CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II, active site (InterPro:IPR008255), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), Thioredoxin reductase (InterPro:IPR005982), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: NADPH-dependent thioredoxin reductase A (TAIR:AT2G17420.1); Has 22764 Blast hits to 22762 proteins in 2961 species: Archae - 698; Bacteria - 15900; Metazoa - 139; Fungi - 313; Plants - 208; Viruses - 0; Other Eukaryotes - 5506 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16842174..16844359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119711.4 → NP_195271.2  NADPH-dependent thioredoxin reductase B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195271.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39243, Q84W20, Q9SVW9
      UniProtKB/TrEMBL
      A0A178UXU0, A0A5S9XZ90, A0A654FVT6
      Conserved Domains (1) summary
      TIGR01292
      Location:55 → 364
      TRX_reduct; thioredoxin-disulfide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39243.3

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