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    BAG6 BCL-2-associated athanogene 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819232, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BAG6
    Official Full Name
    BCL-2-associated athanogene 6
    Primary source
    TAIR:AT2G46240
    Locus tag
    AT2G46240
    See related
    Araport:AT2G46240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA BCL-2-ASSOCIATED ATHANOGENE 6; ATBAG6; BCL-2-associated athanogene 6; T3F17.11
    Summary
    A member of Arabidopsis BAG (Bcl-2-associated athanogene) proteins, plant homologs of mammalian regulators of apoptosis. Expression of BAG6 in leaves was strongly induced by heat stress. Knockout mutants exhibited enhanced susceptibility to fungal pathogen Botrytis cinerea. Plant BAG proteins are multi-functional and remarkably similar to their animal counterparts, as they regulate apoptotic-like processes ranging from pathogen attack, to abiotic stress, to plant development.
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    Genomic context

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    See BAG6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (18986133..18990220)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ABI-1-like 1 Neighboring gene PIN domain-like family protein Neighboring gene myosin heavy chain-like protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Processing of AtBAG6 triggers autophagy and fungal resistance. Li Y, et al. Plant Signal Behav, 2016 Jun 2. PMID 27128431, Free PMC Article
    2. Increased fes1a thermotolerance is induced by BAG6 knockout. Fu C, et al. Plant Mol Biol, 2019 May. PMID 30796711
    3. Identification and functional characterization of the BAG protein family in Arabidopsis thaliana. Doukhanina EV, et al. J Biol Chem, 2006 Jul 7. PMID 16636050
    4. AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants. Kang CH, et al. Cell Death Differ, 2006 Jan. PMID 16003391
    5. Aspartyl Protease-Mediated Cleavage of BAG6 Is Necessary for Autophagy and Fungal Resistance in Plants. Li Y, et al. Plant Cell, 2016 Jan. PMID 26739014, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fes1a bag6 double mutant shows an increased short-term thermotolerance compared to fes1a.
      Title: Increased fes1a thermotolerance is induced by BAG6 knockout.
    2. Arabidopsis BAG6 (AtBAG6) knockout lines exhibited a pronounced enhancement of susceptibility to the necrotrophic fungal pathogen Botrytis cinerea.
      Title: Processing of AtBAG6 triggers autophagy and fungal resistance.
    3. Targeted inactivation of BAGP1 or APCB1 results in the blocking of BAG6 processing and loss of fungal resistance.
      Title: Aspartyl Protease-Mediated Cleavage of BAG6 Is Necessary for Autophagy and Fungal Resistance in Plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130187.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within induction of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    BCL-2-associated athanogene 6
    NP_182147.1
    • BCL-2-associated athanogene 6 (BAG6); CONTAINS InterPro DOMAIN/s: Apoptosis regulator, Bcl-2 protein, BAG (InterPro:IPR003103), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: BCL-2-associated athanogene 5 (TAIR:AT1G12060.1); Has 21821 Blast hits to 15371 proteins in 1199 species: Archae - 184; Bacteria - 2603; Metazoa - 10110; Fungi - 2300; Plants - 994; Viruses - 95; Other Eukaryotes - 5535 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18986133..18990220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130187.4 → NP_182147.1  BCL-2-associated athanogene 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82345
      UniProtKB/TrEMBL
      A0A5S9X7X5
      Conserved Domains (2) summary
      pfam09528
      Location:482 → 969
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00264
      Location:595 → 672
      BAG; BAG domains, present in regulator of Hsp70 proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82345.1

    Gene LinkOut

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