Myo19 myosin XIX [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo19provided by MGI
Official Full Name: myosin XIXprovided by MGI
Primary source: MGI:MGI:1913446
See related: Ensembl:ENSMUSG00000020527 AllianceGenome:MGI:1913446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myohd1; 1110055A02Rik
Summary: Enables ATP hydrolysis activity; myosin light chain binding activity; and plus-end directed microfilament motor activity. Acts upstream of or within mitocytosis. Predicted to be located in cytosol and mitochondrial outer membrane. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Is expressed in several structures, including adenohypophysis; alimentary system; skeleton; submandibular gland primordium; and vomeronasal organ. Orthologous to human MYO19 (myosin XIX). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 17.9), kidney adult (RPKM 12.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.34 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (84770996..84802052)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (84880170..84911226)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo19 is a high-duty ratio molecular motor moving to the plus-end of the actin filament.
Title: Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables plus-end directed microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrion migration along actin filament	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: unconventional myosin-XIX

Names: myosin head domain containing 1; myosin head domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362893.1 → NP_001349822.1 unconventional myosin-XIX isoform 2

Status: VALIDATED

Source sequence(s)

AK080117, AL645623

Related

ENSMUST00000124152.8

Conserved Domains (2) summary

pfam00612
Location:511 → 531

IQ; IQ calmodulin-binding motif

cl22853
Location:18 → 473

Motor_domain; Myosin and Kinesin motor domain
NM_025414.4 → NP_079690.2 unconventional myosin-XIX isoform 1

See identical proteins and their annotated locations for NP_079690.2

Status: VALIDATED

Source sequence(s)

AK018609, AK080117, AL645623, BC060115, BU613548, CA749671

Consensus CDS

CCDS48871.1

UniProtKB/Swiss-Prot

Q5SV80, Q8BH54, Q9D2Z3

Related

ENSMUSP00000091502.5, ENSMUST00000093969.11

Conserved Domains (2) summary

cd14880
Location:49 → 746

MYSc_Myo19; class XIX myosin, motor domain

pfam00612
Location:784 → 804

IQ; IQ calmodulin-binding motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

84770996..84802052

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249173.3 → XP_011247475.1 unconventional myosin-XIX isoform X1

See identical proteins and their annotated locations for XP_011247475.1

UniProtKB/Swiss-Prot

Q5SV80, Q8BH54, Q9D2Z3

Conserved Domains (2) summary

cd14880
Location:49 → 746

MYSc_Myo19; class XIX myosin, motor domain

pfam00612
Location:784 → 804

IQ; IQ calmodulin-binding motif
XM_036156894.1 → XP_036012787.1 unconventional myosin-XIX isoform X5

Related

ENSMUST00000141173.2

Conserved Domains (2) summary

pfam00612
Location:511 → 531

IQ; IQ calmodulin-binding motif

cl22853
Location:18 → 473

Motor_domain; Myosin and Kinesin motor domain
XM_011249174.3 → XP_011247476.1 unconventional myosin-XIX isoform X2

Conserved Domains (2) summary

cl22853
Location:49 → 688

Motor_domain; Myosin and Kinesin motor domain

pfam00612
Location:726 → 746

IQ; IQ calmodulin-binding motif
XM_030246221.1 → XP_030102081.1 unconventional myosin-XIX isoform X4

Conserved Domains (2) summary

pfam00612
Location:575 → 595

IQ; IQ calmodulin-binding motif

cl22853
Location:1 → 537

Motor_domain; Myosin and Kinesin motor domain
XM_036156892.1 → XP_036012785.1 unconventional myosin-XIX isoform X3

Conserved Domains (2) summary

pfam00612
Location:639 → 659

IQ; IQ calmodulin-binding motif

cl22853
Location:1 → 601

Motor_domain; Myosin and Kinesin motor domain
XM_036156893.1 → XP_036012786.1 unconventional myosin-XIX isoform X4

Conserved Domains (2) summary

pfam00612
Location:575 → 595

IQ; IQ calmodulin-binding motif

cl22853
Location:1 → 537

Motor_domain; Myosin and Kinesin motor domain
XM_036156895.1 → XP_036012788.1 unconventional myosin-XIX isoform X5

Conserved Domains (2) summary

pfam00612
Location:511 → 531

IQ; IQ calmodulin-binding motif

cl22853
Location:18 → 473

Motor_domain; Myosin and Kinesin motor domain
XM_006533930.4 → XP_006533993.1 unconventional myosin-XIX isoform X6

Conserved Domains (2) summary

cl22853
Location:1 → 403

Motor_domain; Myosin and Kinesin motor domain

pfam00612
Location:441 → 461

IQ; IQ calmodulin-binding motif