NFXL1 NF-X-like 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NFXL1
Official Full Name: NF-X-like 1
Primary source: TAIR:AT1G10170
Locus tag: AT1G10170
See related: Araport:AT1G10170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATNFXL1; F14N23.5; F14N23_5; NF-X-like 1
Summary: Encodes AtNFXL1, a homologue of the putative human transcription repressor NF-X1. Functions as a negative regulator of the trichothecene phytotoxin-induced defense response.
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Genomic context

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See NFXL1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (3333504..3338188, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis.
Title: NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis.
Data suggest that the Arabidopsis NFXL1 and NFXL2 zinc finger proteins likely are part of regulatory mechanisms, which protect major processes such as photosynthesis. [NFXL1]
Title: The AtNFXL1 gene encodes a NF-X1 type zinc finger protein required for growth under salt stress.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001331888.1

Supported by ESTs:

NM_001331890.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to microbial phytotoxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within salicylic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NF-X-like 1

NP_001318968.1

NF-X-like 1 (NFXL1); FUNCTIONS IN: zinc ion binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, NF-X1-type (InterPro:IPR000967), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: sequence-specific DNA binding transcription factors;zinc ion binding;sequence-specific DNA binding transcription factors (TAIR:AT5G05660.1); Has 6781 Blast hits to 3735 proteins in 261 species: Archae - 0; Bacteria - 123; Metazoa - 4814; Fungi - 547; Plants - 327; Viruses - 10; Other Eukaryotes - 960 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

3333504..3338188 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001331889.1 → NP_001323075.1 NF-X-like 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AVY4, A0A5S9TKI6, A0A654E8D7
NM_100891.3 → NP_172488.1 NF-X-like 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172488.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SY59

UniProtKB/TrEMBL

A0A178WL38, A0A5S9TKI6, A0A654E8D7

Conserved Domains (4) summary

cd06008
Location:503 → 550

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

PRK10811
Location:86 → 215

rne; ribonuclease E; Reviewed

cd16696
Location:222 → 279

RING-CH-C4HC3_NFX1; RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins

cl00297
Location:888 → 963

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
NM_001331888.1 → NP_001318968.1 NF-X-like 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SY59

UniProtKB/TrEMBL

A0A178WL38, A0A5S9TKI6, A0A654E8D7

Conserved Domains (4) summary

cd06008
Location:503 → 550

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

PRK10811
Location:86 → 215

rne; ribonuclease E; Reviewed

cd16696
Location:222 → 279

RING-CH-C4HC3_NFX1; RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins

cl00297
Location:888 → 963

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
NM_001331890.1 → NP_001323074.1 NF-X-like 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AVZ2, A0A5S9TKI6, A0A654E8D7