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    GGH2 gamma-glutamyl hydrolase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844204, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GGH2
    Official Full Name
    gamma-glutamyl hydrolase 2
    Primary source
    TAIR:AT1G78680
    Locus tag
    AT1G78680
    See related
    Araport:AT1G78680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGGH2; gamma-glutamyl hydrolase 2
    Summary
    The Arabidopsis protein AtGGH2 is a gamma-glutamyl hydrolase acting specifically on monoglutamates. The enzyme is involved in the tetrahydrofolate metabolism and located to the vacuole.
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    Genomic context

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    See GGH2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (29593756..29596308)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl hydrolase 1 Neighboring gene gamma-glutamyl hydrolase 3 Neighboring gene Phospholipid/glycerol acyltransferase family protein Neighboring gene BES1/BZR1 homolog 4 Neighboring gene TRICHOME BIREFRINGENCE-LIKE 42

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles. Orsomando G, et al. J Biol Chem, 2005 Aug 12. PMID 15961386
    2. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198500.1
    NM_106515.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gamma-glutamyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables omega peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tetrahydrofolylpolyglutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plant-type cell wall ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-glutamyl hydrolase 2
    NP_001185429.1
    • gamma-glutamyl hydrolase 2 (GGH2); CONTAINS InterPro DOMAIN/s: Peptidase C26, gamma-glutamyl hydrolase (InterPro:IPR015527), Peptidase C26 (InterPro:IPR011697); BEST Arabidopsis thaliana protein match is: gamma-glutamyl hydrolase 1 (TAIR:AT1G78660.2).
    NP_565186.2
    • gamma-glutamyl hydrolase 2 (GGH2); FUNCTIONS IN: omega peptidase activity; INVOLVED IN: tetrahydrofolylpolyglutamate metabolic process; LOCATED IN: vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C26, gamma-glutamyl hydrolase (InterPro:IPR015527), Peptidase C26 (InterPro:IPR011697); BEST Arabidopsis thaliana protein match is: gamma-glutamyl hydrolase 1 (TAIR:AT1G78660.2); Has 406 Blast hits to 402 proteins in 115 species: Archae - 3; Bacteria - 51; Metazoa - 191; Fungi - 0; Plants - 77; Viruses - 0; Other Eukaryotes - 84 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29593756..29596308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198500.1 → NP_001185429.1  gamma-glutamyl hydrolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WF39, F4IBT7
      Conserved Domains (2) summary
      cd01747
      Location:56 → 328
      GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
      pfam07722
      Location:54 → 270
      Peptidase_C26; Peptidase C26

    2. NM_106515.4 → NP_565186.2  gamma-glutamyl hydrolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565186.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65355, Q8VYT0, Q9ZV86
      UniProtKB/TrEMBL
      A0A178WF44, A0A7G2E623
      Conserved Domains (2) summary
      cd01747
      Location:56 → 328
      GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
      pfam07722
      Location:54 → 270
      Peptidase_C26; Peptidase C26
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65355.2

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