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    GEM GRAM domain family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816780, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GEM
    Official Full Name
    GRAM domain family protein
    Primary source
    TAIR:AT2G22475
    Locus tag
    AT2G22475
    See related
    Araport:AT2G22475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GL2-EXPRESSION MODULATOR
    Summary
    Encodes GL2-expression modulator (GEM). Involved in the spatial control of cell division, patterning and differentiation of Arabidopsis root epidermal cells. GEM interacts with CDT1, a DNA replication protein and TTG1 (TRANSPARENT TESTA GLABRA1), a WD40-repeat protein involved in GL2-dependent cell fate decision. GEM seems to participate in the maintenance of a repressor histone H3 epigenetics status of the GL2 and CPC (CAPRICE) promoters.
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    Genomic context

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    See GEM in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (9541128..9545038)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617) Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 2 Neighboring gene phosphofructokinase 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides. Templeton GW, et al. Biochem Biophys Res Commun, 2020 Jul 30. PMID 32513542
    2. GEM, a member of the GRAM domain family of proteins, is part of the ABA signaling pathway. Mauri N, et al. Sci Rep, 2016 Mar 4. PMID 26939893, Free PMC Article
    3. Pathways for epidermal cell differentiation via the homeobox gene GLABRA2: update on the roles of the classic regulator. Lin Q, et al. J Integr Plant Biol, 2012 Oct. PMID 22943441
    4. Identification of a regulatory subunit of protein phosphatase 1 which mediates blue light signaling for stomatal opening. Takemiya A, et al. Plant Cell Physiol, 2013 Jan. PMID 22585556
    5. A chromatin link that couples cell division to root epidermis patterning in Arabidopsis. Caro E, et al. Nature, 2007 May 10. PMID 17450124

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides.
      Title: GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides.
    2. These data suggest that GEM is an abscisic acid-responsive protein that may function downstream of ABI5 as part of the abscisic acid signaling pathway.
      Title: GEM, a member of the GRAM domain family of proteins, is part of the ABA signaling pathway.
    3. GL2 directly regulates genes with various hierarchies in epidermal cell differentiation pathways.
      Title: Pathways for epidermal cell differentiation via the homeobox gene GLABRA2: update on the roles of the classic regulator.
    4. GEM participates in the maintenance of the repressor histone H3K9 methylation status of root patterning genes, providing a link between cell division, fate and differentiation during Arabidopsis root development [GEM]
      Title: A chromatin link that couples cell division to root epidermis patterning in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127813.3
    NM_201781.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of epidermal cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    GRAM domain family protein
    NP_565538.1
    • GL2-EXPRESSION MODULATOR (GEM); CONTAINS InterPro DOMAIN/s: GRAM (InterPro:IPR004182); BEST Arabidopsis thaliana protein match is: GRAM domain family protein (TAIR:AT4G40100.1); Has 360 Blast hits to 359 proteins in 24 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 359; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_973510.1
    • GL2-EXPRESSION MODULATOR (GEM); CONTAINS InterPro DOMAIN/s: GRAM (InterPro:IPR004182); BEST Arabidopsis thaliana protein match is: GRAM domain family protein (TAIR:AT4G40100.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9541128..9545038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127813.3 → NP_565538.1  GRAM domain family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EBW7, Q8GWY9, Q8LBI8, Q8S8F8
      UniProtKB/TrEMBL
      A0A178VMY6, A0A5S9X075, A0A654EV35
      Conserved Domains (1) summary
      cd13222
      Location:186 → 292
      PH-GRAM_GEM; GLABRA 2 expression modulator (GEM) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. NM_201781.1 → NP_973510.1  GRAM domain family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VMY6
      Conserved Domains (1) summary
      cl17171
      Location:186 → 242
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8F8.1

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