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    LACS8 AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814974, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LACS8
    Official Full Name
    AMP-dependent synthetase and ligase family protein
    Primary source
    TAIR:AT2G04350
    Locus tag
    AT2G04350
    See related
    Araport:AT2G04350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    long-chain acyl-CoA synthetase 8; T23O15.3; T23O15_3
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    Genomic context

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    See LACS8 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (1515634..1519308)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene cytoplasmic dynein 2 light intermediate chain Neighboring gene uncharacterized protein Neighboring gene Beta-galactosidase related protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis. Zhao L, et al. Plant J, 2010 Dec. PMID 21143684
    2. Arabidopsis contains nine long-chain acyl-coenzyme a synthetase genes that participate in fatty acid and glycerolipid metabolism. Shockey JM, et al. Plant Physiol, 2002 Aug. PMID 12177484, Free PMC Article
    3. An abscisic acid-responsive protein interaction network for sucrose non-fermenting related kinase1 in abiotic stress response. Carianopol CS, et al. Commun Biol, 2020 Mar 26. PMID 32218501, Free PMC Article
    4. A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Lumba S, et al. Dev Cell, 2014 May 12. PMID 24823379
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LACS8 is expressed in various organs and in the embryo throughout development. Over-expression of LACS8 in the seed does not affect fatty acid content.
      Title: Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126468.4
    NM_179603.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AMP-dependent synthetase and ligase family protein
    NP_178516.1
    • long-chain acyl-CoA synthetase 8 (LACS8); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity, catalytic activity; INVOLVED IN: fatty acid biosynthetic process, metabolic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: long chain acyl-CoA synthetase 9 (TAIR:AT1G77590.1); Has 68120 Blast hits to 56487 proteins in 3592 species: Archae - 1085; Bacteria - 46156; Metazoa - 2682; Fungi - 3484; Plants - 2089; Viruses - 2; Other Eukaryotes - 12622 (source: NCBI BLink).
    NP_849934.1
    • long-chain acyl-CoA synthetase 8 (LACS8); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity, catalytic activity; INVOLVED IN: fatty acid biosynthetic process, metabolic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: long chain acyl-CoA synthetase 9 (TAIR:AT1G77590.1); Has 68120 Blast hits to 56487 proteins in 3592 species: Archae - 1085; Bacteria - 46156; Metazoa - 2682; Fungi - 3484; Plants - 2089; Viruses - 2; Other Eukaryotes - 12622 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1515634..1519308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126468.4 → NP_178516.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940V0, Q9SJD4
      UniProtKB/TrEMBL
      A0A178VSW7, A0A5S9WX47, A0A654ETF2
      Conserved Domains (1) summary
      PLN02387
      Location:42 → 720
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    2. NM_179603.2 → NP_849934.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940V0, Q9SJD4
      UniProtKB/TrEMBL
      A0A178VSW7, A0A5S9WX47, A0A654ETF2
      Conserved Domains (1) summary
      PLN02387
      Location:42 → 720
      PLN02387; long-chain-fatty-acid-CoA ligase family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJD4.1

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