AK-HSDH I aspartate kinase-homoserine dehydrogenase i [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AK-HSDH I
Official Full Name: aspartate kinase-homoserine dehydrogenase i
Primary source: TAIR:AT1G31230
Locus tag: AT1G31230
See related: Araport:AT1G31230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AK-HSDH; ASPARTATE KINASE-HOMOSERINE DEHYDROGENASE; aspartate kinase-homoserine dehydrogenase i; F28K20.19; F28K20_19
Summary: Encodes a bifunctional aspartate kinase/homoserine dehydrogenase. These two activities catalyze the first and the third steps toward the synthesis of the essential amino acids threonine, isoleucine and methionine.
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Genomic context

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See AK-HSDH I in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 18

Sequence:: Chromosome: 1; NC_003070.9 (11158618..11163274, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that mutations in the Asp kinases (AKs) and dual-functional Asp kinase-homoserine dehydrogenases (AK-HSDHs) result in reduced transcript levels and gene product activitiee and increases in the contents of Asp-derived amino acids.
Title: Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents.
analysis of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms
Title: Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_102861.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD+ binding	ISS Inferred from Sequence or Structural Similarity more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables aspartate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables homoserine dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aspartate family amino acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in homoserine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysine biosynthetic process via diaminopimelate	IDA Inferred from Direct Assay more info	PubMed
involved_in lysine biosynthetic process via diaminopimelate	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in threonine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in threonine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: aspartate kinase-homoserine dehydrogenase i

NP_174408.1

aspartate kinase-homoserine dehydrogenase i (AK-HSDH I); FUNCTIONS IN: homoserine dehydrogenase activity, aspartate kinase activity; INVOLVED IN: aspartate family amino acid biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Homoserine dehydrogenase, catalytic (InterPro:IPR001342), Amino acid-binding ACT (InterPro:IPR002912), Aspartate/homoserine dehydrogenase, NAD-binding (InterPro:IPR005106), Aspartate kinase, conserved site (InterPro:IPR018042), Bifunctional aspartokinase/homoserine dehydrogenase I (InterPro:IPR011147), NAD(P)-binding domain (InterPro:IPR016040), Aspartate kinase domain (InterPro:IPR001341), Homoserine dehydrogenase, conserved site (InterPro:IPR019811); BEST Arabidopsis thaliana protein match is: aspartate kinase-homoserine dehydrogenase ii (TAIR:AT4G19710.2); Has 17266 Blast hits to 16993 proteins in 2572 species: Archae - 397; Bacteria - 11403; Metazoa - 7; Fungi - 300; Plants - 257; Viruses - 0; Other Eukaryotes - 4902 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

11158618..11163274 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102861.3 → NP_174408.1 aspartate kinase-homoserine dehydrogenase i [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174408.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GWK9, Q9SA18, Q9SHF9, Q9SW59

UniProtKB/TrEMBL

A0A654EFP0

Conserved Domains (1) summary

PRK09436
Location:86 → 909

thrA; bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional