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    CDKB2;2 cyclin-dependent kinase B2;2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838687, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDKB2;2
    Official Full Name
    cyclin-dependent kinase B2;2
    Primary source
    TAIR:AT1G20930
    Locus tag
    AT1G20930
    See related
    Araport:AT1G20930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cyclin-dependent kinase B2;2; CYCLIN-DEPENDENT KINASE B2;2; F9H16.8; F9H16_8
    Summary
    Cyclin-dependent kinase, expressed in flowers and suspension cell culture, expression peaks during M phase in synchronized cultures. Required for proper organization of the shoot apical meristem and for hormone signaling. Expressed in the shoot apical meristem. Involved in regulation of the G2/M transition of the mitotic cell cycle.
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    Genomic context

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    See CDKB2;2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (7292389..7294746, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ARID/BRIGHT DNA-binding domain-containing protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene Auxin efflux carrier family protein Neighboring gene F-box family protein Neighboring gene Phosphofructokinase family protein Neighboring gene U5 small nuclear ribonucleoprotein helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of B2-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana. Andersen SU, et al. Plant Cell, 2008 Jan. PMID 18223038, Free PMC Article
    2. CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis. Peng L, et al. Dev Biol, 2014 Sep 1. PMID 24951878
    3. Identification of novel cyclin-dependent kinases interacting with the CKS1 protein of Arabidopsis. Boudolf V, et al. J Exp Bot, 2001 Jun. PMID 11432958
    4. Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network. Boruc J, et al. Plant Cell, 2010 Apr. PMID 20407024, Free PMC Article
    5. Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. Nemoto K, et al. Phytochemistry, 2011 Jul. PMID 21477822

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization.
      Title: Requirement of B2-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101946.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hormone-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within hormone-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase B2;2
    NP_173517.1
    • cyclin-dependent kinase B2;2 (CDKB2;2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B2;1 (TAIR:AT1G76540.1); Has 109034 Blast hits to 107606 proteins in 3051 species: Archae - 93; Bacteria - 11427; Metazoa - 41458; Fungi - 12141; Plants - 24398; Viruses - 437; Other Eukaryotes - 19080 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7292389..7294746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101946.4 → NP_173517.1  cyclin-dependent kinase B2;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG64, Q9SYP4
      UniProtKB/TrEMBL
      A0A178W3R6, A0A5S9VDN0, A0A654EBU1
      Conserved Domains (1) summary
      cl21453
      Location:14 → 307
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LG64.2

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