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    TMT1 tonoplast monosaccharide transporter1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838676, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TMT1
    Official Full Name
    tonoplast monosaccharide transporter1
    Primary source
    TAIR:AT1G20840
    Locus tag
    AT1G20840
    See related
    Araport:AT1G20840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTMT1; F9H16.18; F9H16_18; tonoplast monosaccharide transporter1
    Summary
    The protein encoded by this gene is found in the tonoplast (vacuole membrane) of Arabidopsis cells. The gene is expressed at highest levels in juvenile (sink) and adult (source) leaves, followed by flower tissues.
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    Genomic context

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    See TMT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (7244939..7248494, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene tRNA-Trp Neighboring gene multiple chloroplast division site 1 Neighboring gene ncRNA Neighboring gene xylem cysteine peptidase 2 Neighboring gene phosphate transporter 1;8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased activity of the vacuolar monosaccharide transporter TMT1 alters cellular sugar partitioning, sugar signaling, and seed yield in Arabidopsis. Wingenter K, et al. Plant Physiol, 2010 Oct. PMID 20709831, Free PMC Article
    2. A member of the mitogen-activated protein 3-kinase family is involved in the regulation of plant vacuolar glucose uptake. Wingenter K, et al. Plant J, 2011 Dec. PMID 21838775
    3. Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2. Schulz A, et al. Plant J, 2011 Oct. PMID 21668536
    4. Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transport. Wormit A, et al. Plant Cell, 2006 Dec. PMID 17158605, Free PMC Article
    5. Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control. Pulido P, et al. Plant Cell, 2013 Oct. PMID 24104567, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSUC4 most likely catalyses proton-coupled sucrose export from the vacuole within the Arabidopsis cell. However, TMT1/2 probably represents a proton-coupled antiporter capable of high-capacity loading of glucose and sucrose into the vacuole.
      Title: Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2.
    2. VIK-dependent phosphorylation stimulates TMT1 transport activity.
      Title: A member of the mitogen-activated protein 3-kinase family is involved in the regulation of plant vacuolar glucose uptake.
    3. Increased TMT1 activity induced modified subcellular sugar compartmentation, altered cellular sugar sensing, affected assimilate allocation, increased the seed biomass, and accelerated early plant development.
      Title: Increased activity of the vacuolar monosaccharide transporter TMT1 alters cellular sugar partitioning, sugar signaling, and seed yield in Arabidopsis.
    4. These results indicate that TMT1 is involved in vacuolar monosaccharide transport and plays a major role during stress responses.[TMT1]
      Title: Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transport.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332471.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleoside transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to fructose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tonoplast monosaccharide transporter1
    NP_001319055.1
    • tonoplast monosaccharide transporter1 (TMT1); FUNCTIONS IN: carbohydrate transmembrane transporter activity, sugar:hydrogen symporter activity, nucleoside transmembrane transporter activity; INVOLVED IN: in 6 processes; LOCATED IN: plant-type vacuole membrane, plasma membrane, vacuole, membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: tonoplast monosaccharide transporter2 (TAIR:AT4G35300.4); Has 47782 Blast hits to 35006 proteins in 2411 species: Archae - 763; Bacteria - 22324; Metazoa - 7189; Fungi - 11789; Plants - 3723; Viruses - 0; Other Eukaryotes - 1994 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7244939..7248494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101937.6 → NP_173508.1  tonoplast monosaccharide transporter1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96290, Q9LM67, Q9SYQ3
      UniProtKB/TrEMBL
      A0A178W059, A0A5S9VBJ9
      Conserved Domains (1) summary
      cl28910
      Location:10 → 208
      MFS; Major Facilitator Superfamily

    2. NM_001332471.1 → NP_001319055.1  tonoplast monosaccharide transporter1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96290, Q9LM67, Q9SYQ3
      UniProtKB/TrEMBL
      A0A178W059, A0A5S9VBJ9
      Conserved Domains (1) summary
      cl28910
      Location:10 → 208
      MFS; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96290.2

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