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    Gpatch4 G patch domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 66614, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gpatch4provided by MGI
    Official Full Name
    G patch domain containing 4provided by MGI
    Primary source
    MGI:MGI:1913864
    See related
    Ensembl:ENSMUSG00000028069 AllianceGenome:MGI:1913864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpatc4; 2610029K21Rik
    Summary
    Predicted to enable nucleic acid binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Is expressed in central nervous system and sensory organ. Orthologous to human GPATCH4 (G-patch domain containing 4 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.2), liver E14 (RPKM 6.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpatch4 in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87950413..87963301)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88043106..88055994)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene predicted gene, 19439 Neighboring gene STARR-positive B cell enhancer ABC_E10191 Neighboring gene NAD(P)HX epimerase Neighboring gene tetratricopeptide repeat domain 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G patch domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110809.2 → NP_001104279.1  G patch domain-containing protein 4

      See identical proteins and their annotated locations for NP_001104279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK169111, BI658293, CF616874
      Consensus CDS
      CCDS50948.1
      UniProtKB/Swiss-Prot
      Q3TFK5, Q8VCN2, Q9CU32, Q9D3L4
      Related
      ENSMUSP00000029707.8, ENSMUST00000029707.13
      Conserved Domains (1) summary
      pfam01585
      Location:8 → 55
      G-patch; G-patch domain

    2. NM_001286857.1 → NP_001273786.1  G patch domain-containing protein 4

      See identical proteins and their annotated locations for NP_001273786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC080676, BI658293, CF616874
      Consensus CDS
      CCDS50948.1
      UniProtKB/Swiss-Prot
      Q3TFK5, Q8VCN2, Q9CU32, Q9D3L4
      Related
      ENSMUSP00000141786.2, ENSMUST00000193398.2
      Conserved Domains (1) summary
      pfam01585
      Location:8 → 55
      G-patch; G-patch domain

    3. NM_025663.4 → NP_079939.3  G patch domain-containing protein 4

      See identical proteins and their annotated locations for NP_079939.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC137525
      Consensus CDS
      CCDS50948.1
      UniProtKB/Swiss-Prot
      Q3TFK5, Q8VCN2, Q9CU32, Q9D3L4
      Related
      ENSMUSP00000132699.2, ENSMUST00000166021.8
      Conserved Domains (1) summary
      pfam01585
      Location:8 → 55
      G-patch; G-patch domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87950413..87963301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TFK5.1 GenPept UniProtKB/Swiss-Prot:Q3TFK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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