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    AGO1 Stabilizer of iron transporter SufD / Polynucleotidyl transferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841262, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGO1
    Official Full Name
    Stabilizer of iron transporter SufD / Polynucleotidyl transferase
    Primary source
    TAIR:AT1G48410
    Locus tag
    AT1G48410
    See related
    Araport:AT1G48410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARGONAUTE 1; AtAGO1; ICU9; T1N15.2; T1N15_2
    Summary
    Encodes an RNA Slicer that selectively recruits microRNAs and siRNAs. There is currently no evidence that AGO1 Slicer is in a high molecular weight RNA-induced silencing complex (RISC). Mutants are defective in post-transcriptional gene silencing and have pleiotropic developmental and morphological defects. Through its action on the regulation of ARF17 expression, the protein regulates genes involved at the cross talk between auxin and light signaling during adventitious root development. AGO1 seems to be targeted for degradation by silencing suppressor F-box-containing proteins from Turnip yellow virus and Cucurbit aphid-borne yellow virus.
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    Genomic context

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    See AGO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Sequence:
    Chromosome: 1; NC_003070.9 (17885633..17892632, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box/RNI-like/FBD-like domains-containing protein Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene D-cysteine desulfhydrase Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein. Azevedo J, et al. Genes Dev, 2010 May. PMID 20439431, Free PMC Article
    2. Detection of Argonaute 1 Association with Polysomes in Arabidopsis thaliana. Lecampion C, et al. Methods Mol Biol, 2017. PMID 28608339
    3. A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC. Kenesi E, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28499009, Free PMC Article
    4. mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO1. Arribas-Hernández L, et al. Plant Physiol, 2016 Aug. PMID 27208258, Free PMC Article
    5. The Mechanistic Underpinnings of an ago1-Mediated, Environmentally Dependent, and Stochastic Phenotype. Mason GA, et al. Plant Physiol, 2016 Apr. PMID 26872948, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis AGO1 N-terminal extension acts as an essential hub for PRMT5 interaction and post-translational modifications.
      Title: Arabidopsis AGO1 N-terminal extension acts as an essential hub for PRMT5 interaction and post-translational modifications.
    2. Investigating the Interactions of the Cucumber Mosaic Virus 2b Protein with the Viral 1a Replicase Component and the Cellular RNA Silencing Factor Argonaute 1.
      Title: Investigating the Interactions of the Cucumber Mosaic Virus 2b Protein with the Viral 1a Replicase Component and the Cellular RNA Silencing Factor Argonaute 1.
    3. The unique dual targeting of AGO1 by two types of PRMT enzymes promotes phasiRNA loading in Arabidopsis thaliana.
      Title: The unique dual targeting of AGO1 by two types of PRMT enzymes promotes phasiRNA loading in Arabidopsis thaliana.
    4. The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors.
      Title: The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors.
    5. The N-terminal extension of Arabidopsis ARGONAUTE 1 is essential for microRNA activities.
      Title: The N-terminal extension of Arabidopsis ARGONAUTE 1 is essential for microRNA activities.
    6. AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana.
      Title: AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana.
    7. The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA.
      Title: The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA.
    8. The miRNome function transitions from regulating developmental genes to transposable elements during pollen maturation.
      Title: The miRNome function transitions from regulating developmental genes to transposable elements during pollen maturation.
    9. Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants.
      Title: Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants.
    10. Brassinosteroids inhibit miRNA-mediated translational repression by decreasing AGO1 on the endoplasmic reticulum.
      Title: Brassinosteroids inhibit miRNA-mediated translational repression by decreasing AGO1 on the endoplasmic reticulum.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198240.1
    NM_103737.4
    NM_179453.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables miRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNAi-mediated antiviral immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within RNAi-mediated antiviral immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adaxial/abaxial pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adventitious root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within auxin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-transcriptional gene silencing IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Stabilizer of iron transporter SufD / Polynucleotidyl transferase
    NP_001185169.1
    • ARGONAUTE 1 (AGO1); CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Stabilizer of iron transporter SufD / Polynucleotidyl transferase (TAIR:AT5G43810.2).
    NP_175274.1
    • ARGONAUTE 1 (AGO1); FUNCTIONS IN: protein binding, endoribonuclease activity, siRNA binding, miRNA binding; INVOLVED IN: in 11 processes; LOCATED IN: cytosol, nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Stabilizer of iron transporter SufD / Polynucleotidyl transferase (TAIR:AT5G43810.2); Has 29249 Blast hits to 15917 proteins in 1190 species: Archae - 22; Bacteria - 5845; Metazoa - 12576; Fungi - 2412; Plants - 4639; Viruses - 404; Other Eukaryotes - 3351 (source: NCBI BLink).
    NP_849784.1
    • ARGONAUTE 1 (AGO1); FUNCTIONS IN: protein binding, endoribonuclease activity, siRNA binding, miRNA binding; INVOLVED IN: in 11 processes; LOCATED IN: cytosol, nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Stabilizer of iron transporter SufD / Polynucleotidyl transferase (TAIR:AT5G43810.2); Has 29273 Blast hits to 15910 proteins in 1188 species: Archae - 22; Bacteria - 5814; Metazoa - 12632; Fungi - 2415; Plants - 4633; Viruses - 405; Other Eukaryotes - 3352 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17885633..17892632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198240.1 → NP_001185169.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WL72, A0A5S9WPX4
      Conserved Domains (2) summary
      PLN03202
      Location:163 → 1050
      PLN03202; protein argonaute; Provisional
      pfam12764
      Location:79 → 172
      Gly-rich_Ago1; Glycine-rich region of argonaut

    2. NM_179453.3 → NP_849784.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WL72, A0A5S9WPX4
      Conserved Domains (2) summary
      PLN03202
      Location:163 → 1050
      PLN03202; protein argonaute; Provisional
      pfam12764
      Location:79 → 172
      Gly-rich_Ago1; Glycine-rich region of argonaut

    3. NM_103737.4 → NP_175274.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04379, Q0WSQ4, Q3ECU7, Q9LP83
      UniProtKB/TrEMBL
      A0A178WL87, A0A5S9WPX4
      Conserved Domains (2) summary
      PLN03202
      Location:163 → 1048
      PLN03202; protein argonaute; Provisional
      pfam12764
      Location:79 → 172
      Gly-rich_Ago1; Glycine-rich region of argonaut
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04379.1

    Gene LinkOut

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