U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CDKB2;1 cyclin-dependent kinase B2;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843987, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CDKB2;1
    Official Full Name
    cyclin-dependent kinase B2;1
    Primary source
    TAIR:AT1G76540
    Locus tag
    AT1G76540
    See related
    Araport:AT1G76540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cyclin-dependent kinase B2;1; CYCLIN-DEPENDENT KINASE B2;1; F14G6.14; F14G6_14
    Summary
    Encodes a cyclin-dependent protein kinase involved in regulation of the G2/M transition of the mitotic cell cycle. Specifically binds to the cyclin CYCD4;1, expressed in shoot meristem, young leaves and vascular tissue during the G2/M phase. Required for proper organization of the shoot apical meristem and for hormone signaling.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CDKB2;1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (28720328..28722550, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ARID/BRIGHT DNA-binding domain-containing protein Neighboring gene Auxin efflux carrier family protein Neighboring gene Auxin efflux carrier family protein Neighboring gene Phosphofructokinase family protein Neighboring gene CP12 domain-containing protein 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential regulation of B2-type CDK accumulation in Arabidopsis roots. Okushima Y, et al. Plant Cell Rep, 2014 Jul. PMID 24573537
    2. Expression of B2-type cyclin-dependent kinase is controlled by protein degradation in Arabidopsis thaliana. Adachi S, et al. Plant Cell Physiol, 2006 Dec. PMID 17099223
    3. Requirement of B2-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana. Andersen SU, et al. Plant Cell, 2008 Jan. PMID 18223038, Free PMC Article
    4. CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis. Peng L, et al. Dev Biol, 2014 Sep 1. PMID 24951878
    5. A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis. Kono A, et al. Plant Cell Rep, 2006 Jun. PMID 16408177

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CDKB2 level is tightly controlled by multiple pathways to maintain the mitotic activity in developing roots.
      Title: Differential regulation of B2-type CDK accumulation in Arabidopsis roots.
    2. The cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization.
      Title: Requirement of B2-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana.
    3. We propose that the abundance of CDKB2 protein is regulated not only at the transcriptional level, but also through proteasome-mediated protein degradation
      Title: Expression of B2-type cyclin-dependent kinase is controlled by protein degradation in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_106304.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within hormone-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within hormone-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cyclin-dependent kinase B2;1
    NP_177780.1
    • cyclin-dependent kinase B2;1 (CDKB2;1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B2;2 (TAIR:AT1G20930.1); Has 111951 Blast hits to 110345 proteins in 2908 species: Archae - 97; Bacteria - 11880; Metazoa - 41997; Fungi - 12251; Plants - 25980; Viruses - 445; Other Eukaryotes - 19301 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28720328..28722550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106304.3 → NP_177780.1  cyclin-dependent kinase B2;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LF80, Q94EX2, Q9C527
      UniProtKB/TrEMBL
      A0A178WJF2, A0A5S9WV03
      Conserved Domains (1) summary
      cl21453
      Location:12 → 305
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LF80.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools