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    CP12-3 CP12 domain-containing protein 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843989, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CP12-3
    Official Full Name
    CP12 domain-containing protein 3
    Primary source
    TAIR:AT1G76560
    Locus tag
    AT1G76560
    See related
    Araport:AT1G76560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CP12 domain-containing protein 3; F14G6.16; F14G6_16
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    Genomic context

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    See CP12-3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (28728206..28728976)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Auxin efflux carrier family protein Neighboring gene cyclin-dependent kinase B2;1 Neighboring gene Phosphofructokinase family protein Neighboring gene Chlorophyll A-B binding family protein Neighboring gene Squamosa promoter-binding protein-like (SBP domain) transcription factor family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis CP12 mutants have reduced levels of phosphoribulokinase and impaired function of the Calvin-Benson cycle. Elena López-Calcagno P, et al. J Exp Bot, 2017 Apr 1. PMID 28430985, Free PMC Article
    2. CP12-mediated protection of Calvin-Benson cycle enzymes from oxidative stress. Marri L, et al. Biochimie, 2014 Feb. PMID 24211189
    3. In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties. Marri L, et al. J Plant Physiol, 2010 Aug 15. PMID 20399532
    4. Expression analysis of the Arabidopsis CP12 gene family suggests novel roles for these proteins in roots and floral tissues. Singh P, et al. J Exp Bot, 2008. PMID 18974062, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single cp12-1, cp12-2, and cp12-3 mutants do not develop a severe photosynthetic or growth phenotype. In contrast, reductions of both CP12-1 and CP12-2 transcripts lead to reductions in photosynthetic capacity and to slower growth and reduced seed yield. No clear phenotype for CP12-3 was evident.
      Title: Arabidopsis CP12 mutants have reduced levels of phosphoribulokinase and impaired function of the Calvin-Benson cycle.
    2. CP12 in oxygen phototrophs needs to be extended beyond light/dark regulation, and include protection of enzymes belonging to Calvine-Benson cycle from oxidative stress.
      Title: CP12-mediated protection of Calvin-Benson cycle enzymes from oxidative stress.
    3. All CP12 isoforms formed, in vitro, a supramolecular complex with GAPDH and PRK, with comparable inhibitory effects on both enzyme activities.
      Title: In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties.
    4. CP12-1 and CP12-2 expression was detected in the sepals and the style of the flower, while CP12-3 was restricted to the stigma and anthers.
      Title: Expression analysis of the Arabidopsis CP12 gene family suggests novel roles for these proteins in roots and floral tissues.
    Submit: New GeneRIF Correction

    General gene information

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    NM_106306.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nickel cation binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to anoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in cellular response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of reductive pentose-phosphate cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CP12 domain-containing protein 3
    NP_565134.1
    • CP12 domain-containing protein 3 (CP12-3); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: negative regulation of reductive pentose-phosphate cycle; LOCATED IN: chloroplast; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function CP12 (InterPro:IPR003823); BEST Arabidopsis thaliana protein match is: CP12 domain-containing protein 1 (TAIR:AT2G47400.1); Has 242 Blast hits to 242 proteins in 66 species: Archae - 0; Bacteria - 121; Metazoa - 0; Fungi - 0; Plants - 114; Viruses - 0; Other Eukaryotes - 7 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28728206..28728976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106306.3 → NP_565134.1  CP12 domain-containing protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LEL6, Q9C9K2
      UniProtKB/TrEMBL
      A0A178WDK7, A0A5S9WUY3
      Conserved Domains (1) summary
      pfam02672
      Location:65 → 133
      CP12; CP12 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9K2.1

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