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    ACBP4 acyl-CoA binding protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819707, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACBP4
    Official Full Name
    acyl-CoA binding protein 4
    Primary source
    TAIR:AT3G05420
    Locus tag
    AT3G05420
    See related
    Araport:AT3G05420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acyl-CoA binding protein 4; AtACBP4; F22F7.13; F22F7_13
    Summary
    Acyl-CoA binding protein with high affinity for oleoyl-CoA. Expressed in all plant organs. Involved in fatty acid transport.
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    Genomic context

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    See ACBP4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Sequence:
    Chromosome: 3; NC_003074.8 (1561671..1567336)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene Photosystem II reaction center PsbP family protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Tudor/PWWP/MBT superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kelch-motif containing acyl-CoA binding proteins AtACBP4 and AtACBP5 are differentially expressed and function in floral lipid metabolism. Ye ZW, et al. Plant Mol Biol, 2017 Jan. PMID 27826761
    2. Expression of Arabidopsis acyl-CoA-binding proteins AtACBP1 and AtACBP4 confers Pb(II) accumulation in Brassica juncea roots. DU ZY, et al. Plant Cell Environ, 2015 Jan. PMID 24906022
    3. Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester. Xiao S, et al. Plant Physiol Biochem, 2009 Oct. PMID 19589686
    4. Ethylene- and pathogen-inducible Arabidopsis acyl-CoA-binding protein 4 interacts with an ethylene-responsive element binding protein. Li HY, et al. J Exp Bot, 2008. PMID 18836139, Free PMC Article
    5. Arabidopsis acyl-CoA-binding proteins ACBP4 and ACBP5 are subcellularly localized to the cytosol and ACBP4 depletion affects membrane lipid composition. Xiao S, et al. Plant Mol Biol, 2008 Dec. PMID 18773301, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana.
      Title: ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana.
    2. AtACBP4 and AtACBP5 both function in floral lipidic metabolism and play complementary roles in Arabidopsis microspore-to-pollen development.
      Title: Kelch-motif containing acyl-CoA binding proteins AtACBP4 and AtACBP5 are differentially expressed and function in floral lipid metabolism.
    3. The roles of cytosolic AtACBP4, 5 and 6 in floral development were addressed in this study.
      Title: The Arabidopsis cytosolic Acyl-CoA-binding proteins play combinatory roles in pollen development.
    4. AtACBP1 and AtACBP4 can protect lipids against Pb(II)-induced lipid peroxidation.
      Title: Expression of Arabidopsis acyl-CoA-binding proteins AtACBP1 and AtACBP4 confers Pb(II) accumulation in Brassica juncea roots.
    5. Data indicate that the acyl-CoA-binding proteins acbp4acbp5acbp6 mutant showed the lightest seed weight and highest sensitivity to abscisic acid during germination.
      Title: Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development.
    6. Data suggest that light-regulated ACBP4 and ACBP5 are potential candidates for the intracellular transport of oleoyl-CoA ester exported from the chloroplast to the endoplasmic reticulum for the biosynthesis of non-plastidial membrane lipids.
      Title: Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester.
    7. ACBP4 and ACBP5 are available in the cytosol to bind and transfer cytosolic oleoyl-CoA esters
      Title: Arabidopsis acyl-CoA-binding proteins ACBP4 and ACBP5 are subcellularly localized to the cytosol and ACBP4 depletion affects membrane lipid composition.
    8. Interaction of acyl-CoA-binding protein 4 with the ethylene-responsive element binding protein is induced by ethylene.
      Title: Ethylene- and pathogen-inducible Arabidopsis acyl-CoA-binding protein 4 interacts with an ethylene-responsive element binding protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111415.5
    NM_202498.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to light stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-CoA binding protein 4
    NP_187193.3
    • acyl-CoA binding protein 4 (ACBP4); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: lipid transport; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 2 (InterPro:IPR011498), Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), Kelch-type beta propeller (InterPro:IPR015915), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 5 (TAIR:AT5G27630.1); Has 12542 Blast hits to 6987 proteins in 469 species: Archae - 21; Bacteria - 614; Metazoa - 5387; Fungi - 1265; Plants - 2730; Viruses - 3; Other Eukaryotes - 2522 (source: NCBI BLink).
    NP_974227.1
    • acyl-CoA binding protein 4 (ACBP4); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: lipid transport; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 2 (InterPro:IPR011498), Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), Kelch-type beta propeller (InterPro:IPR015915), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 5 (TAIR:AT5G27630.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1561671..1567336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202498.2 → NP_974227.1  acyl-CoA binding protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F5I3
      Conserved Domains (8) summary
      PLN02153
      Location:171 → 416
      PLN02153; epithiospecifier protein
      sd00038
      Location:185 → 241
      Kelch; KELCH repeat [structural motif]
      pfam00887
      Location:14 → 99
      ACBP; Acyl CoA binding protein
      pfam01344
      Location:184 → 225
      Kelch_1; Kelch motif
      pfam09304
      Location:552 → 639
      Cortex-I_coil; Cortexillin I, coiled coil
      pfam13415
      Location:305 → 355
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:395 → 432
      Kelch_5; Kelch motif
      pfam13964
      Location:244 → 296
      Kelch_6; Kelch motif

    2. NM_111415.5 → NP_187193.3  acyl-CoA binding protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187193.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E7F2, Q9MA55
      UniProtKB/TrEMBL
      A0A178VCA4, A0A654F5I3, A0A7G2EG26
      Conserved Domains (4) summary
      PLN02153
      Location:170 → 415
      PLN02153; epithiospecifier protein
      sd00038
      Location:184 → 240
      Kelch; KELCH repeat [structural motif]
      pfam00887
      Location:14 → 99
      ACBP; Acyl CoA binding protein
      pfam01576
      Location:543 → 640
      Myosin_tail_1; Myosin tail
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MA55.1

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