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    POK1 phragmoplast orienting kinesin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820999, updated on 18-Sep-2024

    Summary

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    Official Symbol
    POK1
    Official Full Name
    phragmoplast orienting kinesin 1
    Primary source
    TAIR:AT3G17360
    Locus tag
    AT3G17360
    See related
    Araport:AT3G17360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phragmoplast orienting kinesin 1
    Summary
    PHRAGMOPLAST ORIENTING KINESIN 1 is one of the two Arabidopsis homologs isolated in yeast two-hybrid screen for interaction partners of maize gene TANGLED1 (TAN1). Based on sequence homology in their motor domains, POK1 and POK2 belong to the kinesin-12 class which also includes the well-characterized group of phragmoplast-associated kinesins AtPAKRPs. Both kinesins are composed of an N-terminal motor domain throughout the entire C terminus and putative cargo binding tail domains. The expression domains for POK1 constructs were more limited than those for POK2; both are expressed in tissues enriched for dividing cells. The phenotype of pok1/pok2 double mutants strongly resembles that of maize tan1 mutants, characterized by misoriented mitotic cytoskeletal arrays and misplaced cell walls.
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    Genomic context

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    See POK1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    34
    Sequence:
    Chromosome: 3; NC_003074.8 (5935880..5946540)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene wall-associated receptor kinase carboxy-terminal protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The localization of PHRAGMOPLAST ORIENTING KINESIN1 at the division site depends on the microtubule-binding proteins TANGLED1 and AUXIN-INDUCED IN ROOT CULTURES9 in Arabidopsis. Mills AM, et al. Plant Cell, 2022 Oct 27. PMID 36005863, Free PMC Article
    2. Putative RopGAPs impact division plane selection and interact with kinesin-12 POK1. Stöckle D, et al. Nat Plants, 2016 Aug 8. PMID 27501519
    3. Two kinesins are involved in the spatial control of cytokinesis in Arabidopsis thaliana. Müller S, et al. Curr Biol, 2006 May 9. PMID 16682350
    4. RanGAP1 is a continuous marker of the Arabidopsis cell division plane. Xu XM, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19011093, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The localization of PHRAGMOPLAST ORIENTING KINESIN1 at the division site depends on the microtubule-binding proteins TANGLED1 and AUXIN-INDUCED IN ROOT CULTURES9 in Arabidopsis.
      Title: The localization of PHRAGMOPLAST ORIENTING KINESIN1 at the division site depends on the microtubule-binding proteins TANGLED1 and AUXIN-INDUCED IN ROOT CULTURES9 in Arabidopsis.
    2. In contrast to pok1 pok2 mutants, phgap1 phgap2 double mutants show moderate cell wall positioning defects as a consequence of inaccurate positioning of the cortical division zone marker POK1. We conclude that loss of PHGAP function interferes with division plane selection in proliferative cell divisions.
      Title: Putative RopGAPs impact division plane selection and interact with kinesin-12 POK1.
    3. POK1 and POK2 participate in the spatial control of cytokinesis, perhaps via an interaction with the Arabidopsis TAN1 homolog, ATN. [POK1]
      Title: Two kinesins are involved in the spatial control of cytokinesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001338287.1
    NM_112614.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    phragmoplast orienting kinesin 1
    NP_188362.2
    • phragmoplast orienting kinesin 1 (POK1); FUNCTIONS IN: microtubule motor activity, ATP binding; INVOLVED IN: cytokinesis; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: phragmoplast orienting kinesin 2 (TAIR:AT3G19050.1); Has 97051 Blast hits to 52483 proteins in 2606 species: Archae - 1597; Bacteria - 13842; Metazoa - 45578; Fungi - 8395; Plants - 6409; Viruses - 244; Other Eukaryotes - 20986 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5935880..5946540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338286.1 → NP_001326050.1  phragmoplast orienting kinesin 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LN38, A0A7G2EMA8

    2. NM_112614.4 → NP_188362.2  phragmoplast orienting kinesin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188362.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27IK7, Q9LUT5
      UniProtKB/TrEMBL
      A0A7G2ELF3
      Conserved Domains (3) summary
      smart00129
      Location:168 → 512
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01373
      Location:167 → 514
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
      pfam12711
      Location:629 → 714
      Kinesin-relat_1; Kinesin motor

    3. NM_001338287.1 → NP_001326049.1  phragmoplast orienting kinesin 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LN37, A0A7G2ELF3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27IK7.1

    Gene LinkOut

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