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    Zinc finger C-x8-C-x5-C-x3-H type family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842999, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Zinc finger C-x8-C-x5-C-x3-H type family protein
    Primary source
    TAIR:AT1G66810
    Locus tag
    AT1G66810
    See related
    Araport:AT1G66810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtC3H14; F4N21.6; F4N21_6
    Summary
    Encodes a tandem CCCH zinc finger (TZF) protein that can bind DNA and RNA, function as a transcriptional activator, and is involved in secondary wall biosynthesis.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (24927246..24929054, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene glycine-rich protein Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene PLASTID MOVEMENT IMPAIRED protein (DUF827)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtC3H14, a plant-specific tandem CCCH zinc-finger protein, binds to its target mRNAs in a sequence-specific manner and affects cell elongation in Arabidopsis thaliana. Kim WC, et al. Plant J, 2014 Dec. PMID 25228083
    2. Phosphorylation-mediated inactivation of C3H14 by MPK4 enhances bacterial-triggered immunity in Arabidopsis. Wang D, et al. Plant Physiol, 2022 Oct 27. PMID 35736512, Free PMC Article
    3. The Arabidopsis CCCH protein C3H14 contributes to basal defense against Botrytis cinerea mainly through the WRKY33-dependent pathway. Wang D, et al. Plant Cell Environ, 2020 Jul. PMID 32279333
    4. Arabidopsis C3H14 and C3H15 have overlapping roles in the regulation of secondary wall thickening and anther development. Chai G, et al. J Exp Bot, 2015 May. PMID 25732536
    5. Identification of a cis-acting regulatory motif recognized by MYB46, a master transcriptional regulator of secondary wall biosynthesis. Kim WC, et al. Plant Mol Biol, 2012 Mar. PMID 22271306

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation-mediated inactivation of C3H14 by MPK4 enhances bacterial-triggered immunity in Arabidopsis.
      Title: Phosphorylation-mediated inactivation of C3H14 by MPK4 enhances bacterial-triggered immunity in Arabidopsis.
    2. The Arabidopsis CCCH protein C3H14 contributes to basal defense against Botrytis cinerea mainly through the WRKY33-dependent pathway.
      Title: The Arabidopsis CCCH protein C3H14 contributes to basal defense against Botrytis cinerea mainly through the WRKY33-dependent pathway.
    3. At1g66810 plays a key role in both transcriptional and post-transcriptional regulation.At1g66810 is zinc-finger protein.At1g66810 binds to its target mRNAs in a sequence-specific manner and affects cell elongation.
      Title: AtC3H14, a plant-specific tandem CCCH zinc-finger protein, binds to its target mRNAs in a sequence-specific manner and affects cell elongation in Arabidopsis thaliana.
    4. C3H14 and its homologue C3H15 redundantly regulate secondary wall formation and they additionally function in anther development. [C3H14]
      Title: Arabidopsis C3H14 and C3H15 have overlapping roles in the regulation of secondary wall thickening and anther development.
    5. At1g66810 (AtC3H14) promotor has a cis-acting regulatory motif that is recognized by MYB46.
      Title: Identification of a cis-acting regulatory motif recognized by MYB46, a master transcriptional regulator of secondary wall biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105352.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger C-x8-C-x5-C-x3-H type family protein
    NP_176853.1
    • Zinc finger C-x8-C-x5-C-x3-H type family protein; FUNCTIONS IN: zinc ion binding, nucleic acid binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, CCCH-type (InterPro:IPR000571); BEST Arabidopsis thaliana protein match is: Zinc finger C-x8-C-x5-C-x3-H type family protein (TAIR:AT1G68200.1); Has 998 Blast hits to 914 proteins in 220 species: Archae - 0; Bacteria - 0; Metazoa - 425; Fungi - 99; Plants - 223; Viruses - 0; Other Eukaryotes - 251 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24927246..24929054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334249.1 → NP_001321733.1  Zinc finger C-x8-C-x5-C-x3-H type family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C9N3
      UniProtKB/TrEMBL
      A0A5S9WQ91
      Conserved Domains (1) summary
      COG5063
      Location:230 → 300
      CTH1; CCCH-type Zn-finger protein [General function prediction only]

    2. NM_001334248.1 → NP_001321734.1  Zinc finger C-x8-C-x5-C-x3-H type family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARU8

    3. NM_105352.3 → NP_176853.1  Zinc finger C-x8-C-x5-C-x3-H type family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C9N3
      UniProtKB/TrEMBL
      A0A5S9WQ91
      Conserved Domains (1) summary
      COG5063
      Location:230 → 300
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9N3.1

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