ChiC Glycosyl hydrolase family protein with chitinase insertion domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ChiC
Official Full Name: Glycosyl hydrolase family protein with chitinase insertion domain-containing protein
Primary source: TAIR:AT4G19810
Locus tag: AT4G19810
See related: Araport:AT4G19810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: class V chitinase; T16H5.170; T16H5_170
Summary: ChiC encodes a Class V chitinase that is a part of glycoside hydrolase family 18 based on CAZy groupings. It appears to primarily act as an exochitinase in vitro where it predominantly cleaves a chitobiose (GlcNAc)2 residue from the non-reducing end of a chitin oligosaccharide. However, it shows some minor endochitinase activity in vitro, as well. A putative 24 amino-acid signal peptide may direct this protein to the secretory system and it has been detected in cell wall apoplastic fluid. RT-PCR experiments demonstrate that ChiC transcript levels are increased in response to abscisisc acid, jasmonic acid, and NaCl stress. Microarray results also suggest that transcript levels rise in response to osmotic stress, two fungal pathogens, a bacterial pathogen, and the elicitor flagellin.
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Genomic context

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See ChiC in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (10763206..10765795, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001341373.1

Supported by ESTs:

NM_118101.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables endochitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables exochitinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chitin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chitin catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plant-type cell wall	HDA more info	PubMed
located_in secretory vesicle	HDA more info	PubMed

General protein information

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Preferred Names: Glycosyl hydrolase family protein with chitinase insertion domain-containing protein

NP_001319999.1

Glycosyl hydrolase family protein with chitinase insertion domain; FUNCTIONS IN: cation binding, chitinase activity, hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: cell wall; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, C globular stage; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 18, catalytic domain (InterPro:IPR001223), Chitinase II (InterPro:IPR011583), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: Glycosyl hydrolase family protein with chitinase insertion domain (TAIR:AT4G19820.1); Has 6461 Blast hits to 6286 proteins in 1137 species: Archae - 29; Bacteria - 2687; Metazoa - 1798; Fungi - 1311; Plants - 165; Viruses - 109; Other Eukaryotes - 362 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

10763206..10765795 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001341373.1 → NP_001319999.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O81862, Q0WT03

UniProtKB/TrEMBL

A0A654FQZ6

Conserved Domains (1) summary

cd02879
Location:25 → 359

GH18_plant_chitinase_class_V; The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic ...
NM_118101.4 → NP_193716.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193716.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81862, Q0WT03

UniProtKB/TrEMBL

A0A654FQZ6

Conserved Domains (1) summary

cd02879
Location:25 → 359

GH18_plant_chitinase_class_V; The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic ...