CYP83B1 cytochrome P450, family 83, subfamily B, polypeptide 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CYP83B1
Official Full Name: cytochrome P450, family 83, subfamily B, polypeptide 1
Primary source: TAIR:AT4G31500
Locus tag: AT4G31500
See related: Araport:AT4G31500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ''cytochrome P450; ALTERED TRYPTOPHAN REGULATION 4; ATR4; cytochrome P450; CYTOCHROME P450 MONOOXYGENASE 83B1; F3L17.70; F3L17_70; family 83; polypeptide 1; polypeptide 1''; RED ELONGATED 1; RED1; RNT1; RUNT 1; subfamily B; SUPERROOT 2; SUR2
Summary: Encodes an oxime-metabolizing enzyme in the biosynthetic pathway of glucosinolates. Is required for phytochrome signal transduction in red light. Mutation confers auxin overproduction.
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Genomic context

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See CYP83B1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (15273410..15275404, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Interaction between Arabidopsis SUR2/CYP83B1 and GNOM Indicates the Importance of Stabilizing Local Auxin Accumulation in Lateral Root Initiation.
Title: Genetic Interaction between Arabidopsis SUR2/CYP83B1 and GNOM Indicates the Importance of Stabilizing Local Auxin Accumulation in Lateral Root Initiation.
CYP83B1 specifically metabolizes (E)-p-hydroxyphenylacetaldoxime into an S-alkyl-thiohydroximate.
Title: The bifurcation of the cyanogenic glucoside and glucosinolate biosynthetic pathways.
The role of At4g31500 in auxin and brassinosteroid metabolism.
Title: Arabidopsis gulliver1/SUPERROOT2-7 identifies a metabolic basis for auxin and brassinosteroid synergy.
Arabidopsis reduced epidermal fluorescence5 (ref5-1) mutant has a missense mutation in CYP83B1 and displays defects in glucosinolate biosynthesis and in phenylpropanoid accumulation.
Title: Indole Glucosinolate Biosynthesis Limits Phenylpropanoid Accumulation in Arabidopsis thaliana.
Data indicate that AtDOF4.2-overexpressing increased branching through the up-regulation of three branching-related genes, AtSTM (SHOOT MERISTEMLESS), AtTFL1 (TERMINAL FLOWER1) and AtCYP83B1 (CYTOCHROME P450 83B1).
Title: The transcription factor AtDOF4.2 regulates shoot branching and seed coat formation in Arabidopsis.
Data report that tryptophan auxotroph mutants completely suppressed the abnormalities of auxin over production mutant, superroot2.
Title: Tryptophan auxotroph mutants suppress the superroot2 phenotypes, modulating IAA biosynthesis in arabidopsis.
The complex phenotype of sur2 may thus not only be assigned to elevated levels of auxin, but also to ethylene and abscisic acid responses as well as drought responses in the absence of a water deficiency.
Title: Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2.
Studies demonstrate controlled production of I-GLSs by introducing an ethanol-inducible CYP79B2 construct into double (cyp79b2 cyp79b3) or triple (cyp79b2 cyp79b3 cyp83b1) mutant lines.
Title: Controlled indole-3-acetaldoxime production through ethanol-induced expression of CYP79B2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119299.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adventitious root development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response by callose deposition in cell wall	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within indole glucosinolate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within indoleacetic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within induced systemic resistance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insect	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to red light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within shade avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tryptophan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: cytochrome P450, family 83, subfamily B, polypeptide 1

NP_194878.1

''cytochrome P450, family 83, subfamily B, polypeptide 1'' (CYP83B1); FUNCTIONS IN: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen, oxygen binding; INVOLVED IN: in 9 processes; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 83, subfamily A, polypeptide 1 (TAIR:AT4G13770.1); Has 32513 Blast hits to 32256 proteins in 1630 species: Archae - 47; Bacteria - 2956; Metazoa - 11814; Fungi - 7162; Plants - 9504; Viruses - 6; Other Eukaryotes - 1024 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15273410..15275404 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119299.3 → NP_194878.1 cytochrome P450, family 83, subfamily B, polypeptide 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194878.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65782

UniProtKB/TrEMBL

A0A178USK3, A0A5S9XXM4

Conserved Domains (1) summary

PLN03234
Location:1 → 499

PLN03234; cytochrome P450 83B1; Provisional