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    KCS18 3-ketoacyl-CoA synthase 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829603, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCS18
    Official Full Name
    3-ketoacyl-CoA synthase 18
    Primary source
    TAIR:AT4G34520
    Locus tag
    AT4G34520
    See related
    Araport:AT4G34520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-ketoacyl-CoA synthase 18; FAE1; FATTY ACID ELONGATION1; T4L20.100; T4L20_100
    Summary
    Encodes KCS18, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
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    Genomic context

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    See KCS18 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (16494205..16495842)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene 3-ketoacyl-CoA synthase 17 Neighboring gene NmrA-like negative transcriptional regulator family protein Neighboring gene cryptochrome-interacting basic-helix-loop-helix 1 Neighboring gene F-box protein Neighboring gene Ribosomal protein S25 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18 in Arabidopsis thaliana. Jasinski S, et al. PLoS One, 2012. PMID 23145136, Free PMC Article
    2. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process. Reina-Pinto JJ, et al. Plant Cell, 2009 Apr. PMID 19376931, Free PMC Article
    3. Active-site residues of a plant membrane-bound fatty acid elongase beta-ketoacyl-CoA synthase, FAE1 KCS. Ghanevati M, et al. Biochim Biophys Acta, 2001 Jan 15. PMID 11341960
    4. Design of a Seed-Specific Chimeric Promoter with a Modified Expression Profile to Improve Seed Oil Content. Aoyagi T, et al. Int J Mol Sci, 2018 Jun 5. PMID 29874815, Free PMC Article
    5. Directed tagging of the Arabidopsis FATTY ACID ELONGATION1 (FAE1) gene with the maize transposon activator. James DW Jr, et al. Plant Cell, 1995 Mar. PMID 7734965, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We constructed a chimeric promoter that starts to express in the early stage of seed development, and high-level expression is retained until the later stage by connecting the promoters of the biotin carboxyl carrier protein 2 (BCCP2) gene encoding the BCCP2 subunit of acetyl-CoA carboxylase and the fatty acid elongase 1 (FAE1) gene from Arabidopsis
      Title: Design of a Seed-Specific Chimeric Promoter with a Modified Expression Profile to Improve Seed Oil Content.
    2. KCS18 is a major control point for very long chain fatty acid synthesis in Arabidopsis.
      Title: Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18 in Arabidopsis thaliana.
    3. Nuclei of arrested trichome cells in FAE1 misexpression plants cell-autonomously accumulate high levels of DNA damage, including double-strand breaks characteristic of lipoapoptosis.
      Title: Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_119617.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid elongase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-ketoacyl-CoA synthase 18
    NP_195178.1
    • 3-ketoacyl-CoA synthase 18 (KCS18); FUNCTIONS IN: fatty acid elongase activity, acyltransferase activity; INVOLVED IN: fatty acid elongation, very long-chain fatty acid metabolic process; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: shoot apex, stem, fruit, carpel; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 9 (TAIR:AT2G16280.1); Has 5011 Blast hits to 4998 proteins in 1240 species: Archae - 0; Bacteria - 1718; Metazoa - 0; Fungi - 14; Plants - 3124; Viruses - 0; Other Eukaryotes - 155 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16494205..16495842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119617.2 → NP_195178.1  3-ketoacyl-CoA synthase 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38860
      UniProtKB/TrEMBL
      A0A178UUK5, A0A5S9XYM9, A0A654FVH3
      Conserved Domains (1) summary
      PLN02932
      Location:10 → 491
      PLN02932; 3-ketoacyl-CoA synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38860.1

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