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    VFB2 VIER F-box protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824170, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VFB2
    Official Full Name
    VIER F-box protein 2
    Primary source
    TAIR:AT3G50080
    Locus tag
    AT3G50080
    See related
    Araport:AT3G50080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    VIER F-box proteine 2
    Summary
    Encodes an F-box protein. Based on genetic analysis appears to be functionally redundant with VFB1,3, and 4. When expression of all 4 genes is reduced plants show defects in growth and reduced expression of auxin response genes.
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    Genomic context

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    See VFB2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (18572624..18574548)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 77 Neighboring gene CYCLIN D3;3 Neighboring gene Exonuclease family protein Neighboring gene small RNA degrading nuclease 1 Neighboring gene PTEN 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the VIER F-BOX PROTEINE genes from Arabidopsis reveals their importance for plant growth and development. Schwager KM, et al. Plant Cell, 2007 Apr. PMID 17435085, Free PMC Article
    2. The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. Gagne JM, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12169662, Free PMC Article
    3. F-box proteins in Arabidopsis. Xiao W, et al. Trends Plant Sci, 2000 Nov. PMID 11077244
    4. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
    5. A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins. Kuroda H, et al. PLoS One, 2012. PMID 23166809, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114868.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    VIER F-box protein 2
    NP_566928.1
    • VIER F-box proteine 2 (VFB2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: N-terminal protein myristoylation, ubiquitin-dependent protein catabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364), Leucine-rich repeat, cysteine-containing subtype (InterPro:IPR006553); BEST Arabidopsis thaliana protein match is: SKP1/ASK1-interacting protein 2 (TAIR:AT5G67250.1); Has 4306 Blast hits to 2435 proteins in 203 species: Archae - 0; Bacteria - 23; Metazoa - 1627; Fungi - 317; Plants - 1918; Viruses - 0; Other Eukaryotes - 421 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18572624..18574548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114868.4 → NP_566928.1  VIER F-box protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SN10
      UniProtKB/TrEMBL
      A0A178VA62, A0A384L3J3, A0A5S9XK58, A0A654FFS3, A3KPF1
      Conserved Domains (3) summary
      cd09293
      Location:263 → 410
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:233 → 258
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:42 → 71
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SN10.1

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