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    U1-70K U1 small nuclear ribonucleoprotein-70K [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824230, updated on 18-Sep-2024

    Summary

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    Official Symbol
    U1-70K
    Official Full Name
    U1 small nuclear ribonucleoprotein-70K
    Primary source
    TAIR:AT3G50670
    Locus tag
    AT3G50670
    See related
    Araport:AT3G50670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    U1 small nuclear ribonucleoprotein-70K; U1 SNRNP 70K TRUNCATED PROTEIN; U1SNRNP; U1SNRNP-SPECIFIC PROTEIN
    Summary
    Encodes U1 snRNP 70K
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    Genomic context

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    See U1-70K in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (18826160..18829684, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 superfamily protein Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of a plant U1 snRNP 70K gene: alternative splicing of U1 snRNP 70K pre-mRNAs produces two different transcripts. Golovkin M, et al. Plant Cell, 1996 Aug. PMID 8776903, Free PMC Article
    2. Nuclear localization and in vivo dynamics of a plant-specific serine/arginine-rich protein. Ali GS, et al. Plant J, 2003 Dec. PMID 14675452
    3. The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins. Golovkin M, et al. Plant Cell, 1998 Oct. PMID 9761791, Free PMC Article
    4. The C3H-type zinc finger protein GDS1/C3H42 is a nuclear-speckle-localized protein that is essential for normal growth and development in Arabidopsis. Kim DW, et al. Plant Sci, 2016 Sep. PMID 27457991
    5. Interactions of SR45, an SR-like protein, with spliceosomal proteins and an intronic sequence: insights into regulated splicing. Day IS, et al. Plant J, 2012 Sep. PMID 22563826

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SR45 recruits U1snRNP and U2AF to 5' and 3' splice sites, respectively, by interacting with pre-mRNA, U1-70K and U2AF(35) and modulates alternative splicing (AS).
      Title: Interactions of SR45, an SR-like protein, with spliceosomal proteins and an intronic sequence: insights into regulated splicing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114927.4
    NM_180345.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables U1 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein-70K
    NP_190636.1
    • U1 small nuclear ribonucleoprotein-70K (U1-70K); FUNCTIONS IN: RNA binding, nucleotide binding, nucleic acid binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: U1 small nuclear ribonucleoprotein of 70kDa MW N-terminal (InterPro:IPR022023), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G43370.1); Has 287 Blast hits to 284 proteins in 72 species: Archae - 6; Bacteria - 66; Metazoa - 0; Fungi - 0; Plants - 156; Viruses - 0; Other Eukaryotes - 59 (source: NCBI BLink).
    NP_850676.1
    • U1 small nuclear ribonucleoprotein-70K (U1-70K); FUNCTIONS IN: RNA binding, nucleotide binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: U1 small nuclear ribonucleoprotein of 70kDa MW N-terminal (InterPro:IPR022023), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G43370.1); Has 501 Blast hits to 501 proteins in 191 species: Archae - 0; Bacteria - 0; Metazoa - 216; Fungi - 126; Plants - 97; Viruses - 0; Other Eukaryotes - 62 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18826160..18829684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114927.4 → NP_190636.1  U1 small nuclear ribonucleoprotein-70K [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42378, Q42404
      UniProtKB/TrEMBL
      A0A178VDW4, A0A5S9XJM1
      Conserved Domains (3) summary
      PRK12678
      Location:245 → 395
      PRK12678; transcription termination factor Rho; Provisional
      pfam12220
      Location:40 → 128
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
      cd12236
      Location:137 → 227
      RRM_snRNP70; RNA recognition motif (RRM) found in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins

    2. NM_180345.1 → NP_850676.1  U1 small nuclear ribonucleoprotein-70K [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VEF2
      Conserved Domains (3) summary
      COG0724
      Location:102 → 167
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam12220
      Location:40 → 128
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
      cl17169
      Location:137 → 167
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42404.1

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