HAG1 histone acetyltransferase of the GNAT family 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HAG1
Official Full Name: histone acetyltransferase of the GNAT family 1
Primary source: TAIR:AT3G54610
Locus tag: AT3G54610
See related: Araport:AT3G54610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BGT; BIG TOP; GCN5; general control non-repressible 5; HAC3; HAG01; HAT1; HISTONE ACETYLTRANSFERASE 1; histone acetyltransferase of the GNAT family 1
Summary: Encodes a histone acetyltransferase that is plays a role in the determination of the embryonic root-shoot axis. It is also required to regulate the floral meristem activity by modulating the extent of expression of WUS and AG. In other eukaryotes, this protein is recruited to specific promoters by DNA binding transcription factors and is thought to promote transcription by acetylating the N-terminal tail of histone H3. The enzyme has indeed been shown to catalyse primarily the acetylation of H3 histone with only traces of H4 and H2A/B being acetylated. Non-acetylated H3 peptide or an H3 peptide that had been previously acetylated on K9 both serve as excellent substrates for HAG1-catalyzed acetylation. However, prior acetylation of H3 lysine 14 blocks radioactive acetylation of the peptide by HAG1. HAG1 is specific for histone H3 lysine 14.
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Genomic context

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See HAG1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 13

Sequence:: Chromosome: 3; NC_003074.8 (20213406..20217653)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gibberellin Signaling through RGA Suppresses GCN5 Effects on Arabidopsis Developmental Stages.
Title: Gibberellin Signaling through RGA Suppresses GCN5 Effects on Arabidopsis Developmental Stages.
H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation.
Title: H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation.
GCN5 modulates salicylic acid homeostasis by regulating H3K14ac levels at the 5' and 3' ends of its target genes.
Title: GCN5 modulates salicylic acid homeostasis by regulating H3K14ac levels at the 5' and 3' ends of its target genes.
the histone acetyltransferase HAG1/AtGCN5 is essential for de novo shoot regeneration.
Title: Epigenetic reprogramming by histone acetyltransferase HAG1/AtGCN5 is required for pluripotency acquisition in Arabidopsis.
CLV1 and GCN5 are regulators of apical-basal and mediolateral polarity of the Arabidopsis gynoecium.
Title: Synergistic action of GCN5 and CLAVATA1 in the regulation of gynoecium development in Arabidopsis thaliana.
required, with ADA2b, in leaves and trichomes to couple nuclear content with cell growth and morphogenesis
Title: The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis.
we find that INO can directly interact with ADA2b/PROPORZ1 (PRZ1), a transcriptional coactivator that is known to interact with the histone acetyltransferase GENERAL CONTROL NONREPRESSIBLE PROTEIN 5 (GCN5, also known as HAG1).
Title: Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors.
Histone acetyltransferase general control non-repressed protein 5 (GCN5) affects the fatty acid composition of Arabidopsis thaliana seeds by acetylating fatty acid desaturase3 (FAD3).
Title: Histone acetyltransferase general control non-repressed protein 5 (GCN5) affects the fatty acid composition of Arabidopsis thaliana seeds by acetylating fatty acid desaturase3 (FAD3).
signals from the CLV transduction pathway reach the GCN5-containing complexes in the nucleus and alter the histone acetylation status of ethylene-responsive genes.
Title: Synergistic action of histone acetyltransferase GCN5 and receptor CLAVATA1 negatively affects ethylene responses in Arabidopsis thaliana.
It was concluded that these data indicate that GCN5 plays a key role in the preservation of thermotolerance via versatile regulation in Arabidopsis.
Title: Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_115318.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of wax biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of wax biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vegetative phase change	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: histone acetyltransferase of the GNAT family 1

NP_567002.1

histone acetyltransferase of the GNAT family 1 (HAG1); FUNCTIONS IN: histone acetyltransferase activity, DNA binding, H3 histone acetyltransferase activity; INVOLVED IN: flower development, histone acetylation, response to light stimulus, positive regulation of transcription, root morphogenesis; LOCATED IN: histone acetyltransferase complex, nucleus; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), GCN5-related N-acetyltransferase (InterPro:IPR000182), Bromodomain, conserved site (InterPro:IPR018359), Acyl-CoA N-acyltransferase (InterPro:IPR016181), Bromodomain (InterPro:IPR001487); BEST Arabidopsis thaliana protein match is: nuclear protein X1 (TAIR:AT5G63320.1); Has 13698 Blast hits to 5805 proteins in 367 species: Archae - 4; Bacteria - 1437; Metazoa - 4852; Fungi - 1484; Plants - 516; Viruses - 1; Other Eukaryotes - 5404 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

20213406..20217653

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115318.3 → NP_567002.1 histone acetyltransferase of the GNAT family 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567002.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22654, Q7G1G9, Q9AR19, Q9M1G7

UniProtKB/TrEMBL

A0A178VL29, A0A5S9XKX3, A0A654FFS2

Conserved Domains (2) summary

cd05509
Location:459 → 559

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:202 → 553

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]