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    FLS3 flavonol synthase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836478, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLS3
    Official Full Name
    flavonol synthase 3
    Primary source
    TAIR:AT5G63590
    Locus tag
    AT5G63590
    See related
    Araport:AT5G63590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFLS3; FLAVONOL SYNTHASE; flavonol synthase 3; FLS; MBK5.5; MBK5_5
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    Genomic context

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    See FLS3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (25456910..25458639, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glutamate-1-semialdehyde-2,1-aminomutase Neighboring gene flavonol synthase 2 Neighboring gene flavonol synthase 4 Neighboring gene flavonol synthase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana expresses a second functional flavonol synthase. Preuss A, et al. FEBS Lett, 2009 Jun 18. PMID 19433090
    2. Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonols. Chua CS, et al. Phytochemistry, 2008 Jan. PMID 17719613
    3. Characterization of flavonol synthase and leucoanthocyanidin dioxygenase genes in Arabidopsis. Further evidence for differential regulation of "early" and "late" genes. Pelletier MK, et al. Plant Physiol, 1997 Apr. PMID 9112784, Free PMC Article
    4. Functional analysis of a predicted flavonol synthase gene family in Arabidopsis. Owens DK, et al. Plant Physiol, 2008 Jul. PMID 18467451, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification of FLS3 as a second active FLS. This enzyme is likely responsible for the formation of flavonols in the ldox/fls1-2 double mutant.
      Title: Arabidopsis thaliana expresses a second functional flavonol synthase.
    2. structure activity relatiionship of FLS
      Title: Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonols.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125754.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavonol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavonol synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flavonoid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within flavonol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    flavonol synthase 3
    NP_201164.1
    • flavonol synthase 3 (FLS3); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 1 (TAIR:AT5G08640.2); Has 8006 Blast hits to 7970 proteins in 965 species: Archae - 0; Bacteria - 1024; Metazoa - 86; Fungi - 741; Plants - 4902; Viruses - 0; Other Eukaryotes - 1253 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25456910..25458639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125754.3 → NP_201164.1  flavonol synthase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201164.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDA5, Q9FFQ5
      UniProtKB/TrEMBL
      A0A178UJU0, A0A654GE86
      Conserved Domains (1) summary
      PLN02997
      Location:10 → 297
      PLN02997; flavonol synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFQ5.1

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