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    ADA2B ADA2 2B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827336, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADA2B
    Official Full Name
    ADA2 2B
    Primary source
    TAIR:AT4G16420
    Locus tag
    AT4G16420
    See related
    Araport:AT4G16420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DL4235C; FCAALL.57; homolog of yeast ADA2 2B; PROPORZ1; PRZ1
    Summary
    Transcriptional co-activator. Essential for the developmental switch from cell proliferation to cell differentiation in response to variations in auxin and cytokinin concentrations.
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    Genomic context

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    See ADA2B in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (9262621..9266157, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene ferredoxin hydrogenase Neighboring gene Uncharacterized protein family (UPF0497)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses. Vlachonasios KE, et al. Plant Signal Behav, 2011 Oct. PMID 21897124, Free PMC Article
    2. Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression. Vlachonasios KE, et al. Plant Cell, 2003 Mar. PMID 12615937, Free PMC Article
    3. Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin. Anzola JM, et al. Proc Natl Acad Sci U S A, 2010 Jun 1. PMID 20479223, Free PMC Article
    4. PROPORZ1, a putative Arabidopsis transcriptional adaptor protein, mediates auxin and cytokinin signals in the control of cell proliferation. Sieberer T, et al. Curr Biol, 2003 May 13. PMID 12747832
    5. Arabidopsis F-box protein At1g08710 interacts with transcriptional protein ADA2b and imparts drought stress tolerance by negatively regulating seedling growth. Rao V, et al. Biochem Biophys Res Commun, 2021 Jan 15. PMID 33360542

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis.
      Title: Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis.
    2. Arabidopsis F-box protein At1g08710 interacts with transcriptional protein ADA2b and imparts drought stress tolerance by negatively regulating seedling growth.
      Title: Arabidopsis F-box protein At1g08710 interacts with transcriptional protein ADA2b and imparts drought stress tolerance by negatively regulating seedling growth.
    3. Results show that the interaction between transcriptional coactivator ALTERATION/DEFICIENCY IN ACTIVATION2B (ADA2b) and structural maintenance of chromosomes 5 (SMC5) mediates DNA repair in plant cells.
      Title: The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.
    4. required, with GCN5, in leaves and trichomes to couple nuclear content with cell growth and morphogenesis
      Title: The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis.
    5. we find that INO can directly interact with ADA2b/PROPORZ1 (PRZ1), a transcriptional coactivator that is known to interact with the histone acetyltransferase GENERAL CONTROL NONREPRESSIBLE PROTEIN 5 (GCN5, also known as HAG1).
      Title: Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors.
    6. ADA2b is required for the expression of genes involved in abiotic stress either by controlling H3 and H4 acetylation.
      Title: The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses.
    7. The role of SGF29a and ADA2b in salt stress responses, was explored
      Title: Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses.
    8. PRZ1 is involved in the modulation of histone modifications and corresponding adjustments in gene expression of KIP RELATED PROTEIN (KRP) CDK inhibitor genes in response to auxin.
      Title: Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin.
    9. Data suggest that ADA2a and ADA2b each work independently with GCN5 to affect genome function in Arabidopsis.
      Title: Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117737.5
    NM_202831.3
    NM_202832.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ADA2 2B
    NP_567495.1
    • homolog of yeast ADA2 2B (ADA2B); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), SWIRM (InterPro:IPR007526), SANT, eukarya (InterPro:IPR017884), Zinc finger, ZZ-type (InterPro:IPR000433), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2A (TAIR:AT3G07740.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974560.1
    • homolog of yeast ADA2 2B (ADA2B); CONTAINS InterPro DOMAIN/s: SANT, eukarya (InterPro:IPR017884), SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), SWIRM (InterPro:IPR007526), Zinc finger, ZZ-type (InterPro:IPR000433), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2A (TAIR:AT3G07740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974561.1
    • homolog of yeast ADA2 2B (ADA2B); CONTAINS InterPro DOMAIN/s: SANT, eukarya (InterPro:IPR017884), SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), SWIRM (InterPro:IPR007526), Zinc finger, ZZ-type (InterPro:IPR000433), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2A (TAIR:AT3G07740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9262621..9266157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202831.3 → NP_974560.1  ADA2 2B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F0W4
      Conserved Domains (1) summary
      COG5114
      Location:41 → 479
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    2. NM_117737.5 → NP_567495.1  ADA2 2B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23486, Q3EA06, Q3EA07, Q9ATB4
      UniProtKB/TrEMBL
      A0A654FQ35, A0A7G2EYJ2
      Conserved Domains (1) summary
      COG5114
      Location:41 → 483
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    3. NM_202832.2 → NP_974561.1  ADA2 2B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XTU9, A0A7G2F181
      Conserved Domains (1) summary
      COG5114
      Location:41 → 482
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ATB4.1

    Gene LinkOut

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