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    IntS14 Integrator 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IntS14provided by FlyBase
    Official Full Name
    Integrator 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0031314
    Locus tag
    Dmel_CG4785
    See related
    AllianceGenome:FB:FBgn0031314
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4785; Dmel\CG4785; Q9VPY0
    Summary
    Involved in snRNA 3'-end processing. Located in nucleus. Part of integrator complex. Is expressed in organism. Orthologous to human INTS14 (integrator complex subunit 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IntS14 in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1164443..1166425)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1164443..1166425)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phospholipase A2 activator protein Neighboring gene uncharacterized protein Neighboring gene charon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Whittaker CA, et al. Mol Biol Cell, 2002 Oct. PMID 12388743, Free PMC Article
    2. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
    3. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article
    4. Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. Huang KL, et al. Mol Cell, 2020 Oct 15. PMID 32966759, Free PMC Article
    5. IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events. Fujiwara R, et al. Mol Cell, 2023 Dec 21. PMID 37995689, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional and biochemical experiments revealed that Asunder and CG4785 are additional core members of the Integrator complex.
      Title: An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrator 14
    Names
    CG4785-PA
    IntS14-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1164443..1166425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134735.2 → NP_608579.1  integrator 14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPY0
      Related
      FBpp0077627
      Conserved Domains (1) summary
      smart00327
      Location:5 → 164
      VWA; von Willebrand factor (vWF) type A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPY0.1 Q9VPY0

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