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    fal falten [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    falprovided by FlyBase
    Official Full Name
    faltenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028380
    Locus tag
    Dmel_CG9670
    See related
    AllianceGenome:FB:FBgn0028380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9670; Dmel\CG9670; Q9VVY4_DROME
    Summary
    Predicted to enable dGTPase activity. Predicted to be involved in dGTP catabolic process. Predicted to be active in nucleus. Is expressed in gonad and organism. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fal in Genome Data Viewer
    Location:
    76A5-76A5; 3-45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19294564..19298830)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19287867..19291930)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycogen binding subunit 76A Neighboring gene antisense RNA:CR46048 Neighboring gene pipe Neighboring gene uncharacterized protein Neighboring gene male sterile (3) 76Ba Neighboring gene long non-coding RNA:CR43966

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila dorsoventral determinant PIPE contains ten copies of a variable domain homologous to mammalian heparan sulfate 2-sulfotransferase. Sergeev P, et al. Dev Dyn, 2001 Feb. PMID 11169845
    2. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343
    3. On-bead tryptic proteolysis: an attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. Fukuyama H, et al. J Proteomics, 2012 Aug 3. PMID 22450469
    4. Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes. Clough E, et al. Dev Cell, 2014 Dec 22. PMID 25535918, Free PMC Article
    5. Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. Greil F, et al. Genes Dev, 2003 Nov 15. PMID 14630943, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dGTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dGTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    falten
    Names
    CG9670-PB
    CG9670-PC
    CG9670-PD
    fal-PB
    fal-PC
    fal-PD
    NP_001137974.1
    NP_001303382.1
    NP_536789.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19294564..19298830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316453.1 → NP_001303382.1  falten, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z075, Q7K4R8, Q9VVY4
      Conserved Domains (1) summary
      cd00077
      Location:48 → 210
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    2. NM_080528.3 → NP_536789.3  falten, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536789.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z075, Q7K4R8, Q9VVY4
      Conserved Domains (1) summary
      cd00077
      Location:48 → 210
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    3. NM_001144502.2 → NP_001137974.1  falten, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z075, Q7K4R8, Q9VVY4
      Conserved Domains (1) summary
      cd00077
      Location:48 → 210
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4R8 Q7K4R8
    Q965E5 Q965E5
    Q9VVY4 Q9VVY4

    Gene LinkOut

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