CycK Cyclin K [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CycKprovided by FlyBase
Official Full Name: Cyclin Kprovided by FlyBase
Primary source: FLYBASE:FBgn0025674
Locus tag: Dmel_CG15218
See related: AllianceGenome:FB:FBgn0025674
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15218; cycK; Dmel\CG15218
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of DNA-templated transcription, elongation and positive regulation of transcription by RNA polymerase II. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 40E4-40E4; 2-54 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (22124285..22130142, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (22124285..22130142, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c22124431-22124331 mobile_element_type = transposon:INE-1{}6109
Loc: c22124682-22124627 mobile_element_type = transposon:INE-1{}6110

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin K

Names: CG15218-PA; CG15218-PB; CG15218-PC; CycK-PA; CycK-PB; CycK-PC; CyclinK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

22124285..22130142 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299202.1 → NP_001286131.1 cyclin K, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286131.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961D1

Conserved Domains (1) summary

cd00043
Location:30 → 128

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_176069.4 → NP_788083.1 cyclin K, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788083.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961D1

Related

FBpp0085296

Conserved Domains (1) summary

cd00043
Location:30 → 128

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_176068.3 → NP_788082.1 cyclin K, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788082.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961D1

Related

FBpp0085295

Conserved Domains (1) summary

cd00043
Location:30 → 128

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...