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    vito viriato [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vitoprovided by FlyBase
    Official Full Name
    viriatoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052418
    Locus tag
    Dmel_CG32418
    See related
    AllianceGenome:FB:FBgn0052418
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10569; CG32418; Dmel\CG32418
    Summary
    Predicted to enable rRNA binding activity. Involved in several processes, including eye-antennal disc development; nucleolus organization; and positive regulation of imaginal disc growth. Located in nucleolus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; and imaginal disc. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vito in Genome Data Viewer
    Location:
    64E7-64E7; 3-15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5776324..5777333, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5769424..5770433, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45831 Neighboring gene Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase Neighboring gene scrawny Neighboring gene Myt1 Neighboring gene antisense RNA:CR45026 Neighboring gene Peptidoglycan recognition protein LD Neighboring gene Pmi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. Marinho J, et al. Development, 2011 Jan. PMID 21177347
    2. The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development. Marinho J, et al. Dev Biol, 2013 May 1. PMID 23416177
    3. TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands. Martins T, et al. Open Biol, 2017 Jan. PMID 28123053, Free PMC Article
    4. Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila. Logeay R, et al. Development, 2022 Feb 1. PMID 35005772
    5. Gene expression profiling of brakeless mutant Drosophila embryos. Crona F, et al. Data Brief, 2015 Dec. PMID 26509186, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. viriato acts downstream of dMyc to ensure a coordinated nucleolar response to dMyc-induced growth and, thereby, normal organ development (viriato)
      Title: The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth.
    2. A strong genetic interaction between vito and members of the Dpp signaling pathway, was found during drosophila eye development.
      Title: The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye-antennal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    viriato
    Names
    CG32418-PA
    vito-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5776324..5777333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168136.2 → NP_729096.1  viriato [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWS7
      Related
      FBpp0076825
      Conserved Domains (1) summary
      pfam09805
      Location:2 → 149
      Nop25; Nucleolar protein 12 (25kDa)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWS7 Q8SWS7

    Gene LinkOut

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