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    Piezo piezo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Piezoprovided by FlyBase
    Official Full Name
    piezoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264953
    Locus tag
    Dmel_CG44122
    See related
    AllianceGenome:FB:FBgn0264953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.32; CG18103; CG31608; CG44122; CG8486; clone 1.32; Dmel\CG44122; Dmpiezo; DmPiezo; DmPIEZO; fos28F; fos500; OrfKD; piezo
    Old locus tag
    Dmel_CG18103; Dmel_CG8486
    Summary
    Enables mechanosensitive monoatomic ion channel activity. Involved in several processes, including cellular response to mechanical stimulus; detection of temperature stimulus involved in sensory perception of pain; and mechanosensory behavior. Located in plasma membrane. Is expressed in several structures, including antennal primordium; epithelium; head epidermis primordium; larval imaginal tissue; and sensory neurons. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1; distal arthrogryposis type 3; distal arthrogryposis type 5; and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)) and PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Piezo in Genome Data Viewer
    Location:
    28E9-28F1; 2-30 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8163073..8190137)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8163073..8190137)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rabenosyn-5 Neighboring gene Acyl-CoA binding protein 1 Neighboring gene antisense RNA:CR44116 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenic Tarantula Toxin: A novel tool to study mechanosensitive ion channels in Drosophila. Beqja D, et al. J Insect Physiol, 2020 Nov-Dec. PMID 32991864, Free PMC Article
    2. Piezo acts as a molecular brake on wound closure to ensure effective inflammation and maintenance of epithelial integrity. Zechini L, et al. Curr Biol, 2022 Aug 22. PMID 35835122, Free PMC Article
    3. Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons. Suslak TJ, et al. PLoS One, 2015. PMID 26186008, Free PMC Article
    4. The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization. Tokusumi Y, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28342875
    5. Reverse engineering morphogenesis through Bayesian optimization of physics-based models. Kumar N, et al. NPJ Syst Biol Appl, 2024 May 7. PMID 38714708, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency.
      Title: Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency.
    2. Control of feeding by Piezo-mediated gut mechanosensation in Drosophila.
      Title: Control of feeding by Piezo-mediated gut mechanosensation in Drosophila.
    3. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor.
      Title: Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor.
    4. Dissemination of Ras(V12)-transformed cells requires the mechanosensitive channel Piezo.
      Title: Dissemination of Ras(V12)-transformed cells requires the mechanosensitive channel Piezo.
    5. Pzl functions in larval chordotonal neurons to sense proprioceptive information.
      Title: Piezo-like Gene Regulates Locomotion in Drosophila Larvae.
    6. DmPiezo, a Ca(2+)-permeable non-selective cation channel, functions as an intrinsic inhibitor for axon regeneration.
      Title: The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.
    7. Both vertebrate and invertebrate mechanosensitive PIEZO ion channels are polymodal, being voltage modulated, and can even be directly voltage gated following a preceding mechanical stimulus.
      Title: Voltage gating of mechanosensitive PIEZO channels.
    8. demonstration of the existence of a specific group of stem cells in the fly midgut that can directly sense mechanical signals through Piezo
      Title: Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.
    9. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge.
      Title: The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.
    10. The mechanosensory channel, Piezo, has been identifieded in larval drosophila dorsal bipolar dendritic sensory neurons, with TRPA1 playing a subsidiary role.
      Title: Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    piezo
    Names
    CG44122-PE
    CG44122-PF
    CG44122-PG
    CG44122-PH
    CG44122-PI
    CG44122-PJ
    CG44122-PK
    CG44122-PL
    CG44122-PM
    CG44122-PO
    CG44122-PP
    Piezo-PE
    Piezo-PF
    Piezo-PG
    Piezo-PH
    Piezo-PI
    Piezo-PJ
    Piezo-PK
    Piezo-PL
    Piezo-PM
    Piezo-PO
    Piezo-PP
    dmpiezo
    fos-related gene at 28F

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8163073..8190137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273297.1 → NP_001260226.1  piezo, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF50
      Conserved Domains (2) summary
      pfam12166
      Location:2109 → 2539
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1319 → 1513
      PIEZO; Piezo

    2. NM_164795.6 → NP_723354.3  piezo, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723354.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG4
      Conserved Domains (2) summary
      pfam12166
      Location:2247 → 2677
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1300 → 1494
      PIEZO; Piezo

    3. NM_001042881.5 → NP_001036346.3  piezo, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036346.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8L0
      Conserved Domains (2) summary
      pfam12166
      Location:2209 → 2639
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1300 → 1494
      PIEZO; Piezo

    4. NM_001273298.1 → NP_001260227.1  piezo, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB69
      Conserved Domains (2) summary
      pfam12166
      Location:2089 → 2519
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1248 → 1420
      PIEZO; Piezo

    5. NM_001201789.2 → NP_001188718.1  piezo, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRE5
      Conserved Domains (2) summary
      pfam12166
      Location:2108 → 2538
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1245 → 1439
      PIEZO; Piezo

    6. NM_001316385.1 → NP_001303314.1  piezo, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WGQ9
      Conserved Domains (2) summary
      pfam12166
      Location:2511 → 2941
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1363
      PIEZO; Piezo

    7. NM_001273300.2 → NP_001260229.2  piezo, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCW8
      Conserved Domains (2) summary
      pfam12166
      Location:2376 → 2806
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1363
      PIEZO; Piezo

    8. NM_001169436.3 → NP_001162907.1  piezo, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHB4
      Conserved Domains (2) summary
      pfam12166
      Location:2224 → 2654
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1420
      PIEZO; Piezo

    9. NM_001273299.1 → NP_001260228.1  piezo, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCC7
      Conserved Domains (2) summary
      pfam12166
      Location:2071 → 2501
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1420
      PIEZO; Piezo

    10. NM_001201790.2 → NP_001188719.1  piezo, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H6X2P4, M9MSG8
      Conserved Domains (2) summary
      pfam12166
      Location:2089 → 2519
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1420
      PIEZO; Piezo

    11. NM_135344.6 → NP_609188.4  piezo, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609188.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLS3
      Conserved Domains (2) summary
      pfam12166
      Location:2159 → 2589
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1245 → 1439
      PIEZO; Piezo
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WGQ9 A0A0S0WGQ9
    E1JHB4 E1JHB4
    M9MRE5 M9MRE5
    M9MSG8.1 M9MSG8
    M9PB69 M9PB69
    M9PCC7 M9PCC7
    M9PCW8 M9PCW8
    M9PF50 M9PF50
    Q0E8L0 Q0E8L0
    Q24436 Q24436
    Q8IPG4 Q8IPG4
    Q9VLS3 Q9VLS3

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