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    Sptz Spastizin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sptzprovided by FlyBase
    Official Full Name
    Spastizinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037897
    Locus tag
    Dmel_CG5270
    See related
    AllianceGenome:FB:FBgn0037897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5270; D-Sptz; Dmel\CG5270; sptz
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in autophagy. Predicted to be active in centrosome and midbody. Is expressed in several structures, including adult midgut progenitor cell; amnioserosa; embryonic/larval midgut; spermatozoon; and yolk nucleus. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sptz in Genome Data Viewer
    Location:
    86E5-86E5; 3-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11422092..11429969)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7247814..7255691)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ninaG Neighboring gene Ribosomal protein L24-like Neighboring gene D-aminoacyl-tRNA deacylase Neighboring gene uncharacterized protein Neighboring gene Exonuclease 3'-5' domain-containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia. Vantaggiato C, et al. Brain, 2023 Mar 1. PMID 36029068, Free PMC Article
    2. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
    3. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    4. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article
    5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spastizin
    Names
    CG5270-PB
    D-Spastizin
    Sptz-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11422092..11429969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169389.3 → NP_731570.2  spastizin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731570.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NZ0, Q961I5, Q9VGP1
      Related
      FBpp0081863
      Conserved Domains (1) summary
      cl22851
      Location:1441 → 1500
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGP1.3 Q9VGP1

    Gene LinkOut

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