ninaC neither inactivation nor afterpotential C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ninaCprovided by FlyBase
Official Full Name: neither inactivation nor afterpotential Cprovided by FlyBase
Primary source: FLYBASE:FBgn0002938
Locus tag: Dmel_CG5125
See related: AllianceGenome:FB:FBgn0002938
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2.2; CG 5125; CG5125; CG54125; CT16120; CT42491; Dm NinaC; Dmel\CG5125; DRONINAC; Myo1B; Nina C; NINA C; ninac; NinaC; NINAC
Summary: Enables calmodulin binding activity; phosphatidylinositol binding activity; and protein serine/threonine kinase activity. Involved in several processes, including photoreceptor cell maintenance; phototransduction; and protein localization to rhabdomere. Located in cytoplasm; nucleus; and rhabdomere membrane. Part of inaD signaling complex. Is expressed in embryonic head epidermis; embryonic head sensory system; eye; head; and rhabdomere. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 90 and autosomal recessive nonsyndromic deafness 30. Orthologous to several human genes including MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27F3-27F3; 2-26 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7377702..7384344)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7377702..7384344)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rapid calcium (Ca2+)/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction.
Title: Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.
Termination of phototransduction requires a complex with NINAC and retinophilin, a complex which provides stability to protein kinase C and INAD (inactivation no afterpotential D).
Title: Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction.
Data suggest that the photoreceptor-specific myosin III NINAC is involved in G(q)alpha transport in Drosophila photoreceptors.
Title: Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC.
The light-dependent translocation of Arr2 into Drosophila rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III.
Title: Light-dependent translocation of visual arrestin regulated by the NINAC myosin III.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables protein tyrosine kinase activity	IKR Inferred from Key Residues more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction, UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction, visible light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to rhabdomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament length	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of inaD signaling complex	IPI Inferred from Physical Interaction more info	PubMed
part_of inaD signaling complex	TAS Traceable Author Statement more info	PubMed
part_of myosin III complex	NAS Non-traceable Author Statement more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neither inactivation nor afterpotential C

Names: CG5125-PA; CG5125-PB; CG5125-PC; CG5125-PD; NINAC myosin III; droninac; either inactivation nor afterpotential C; myosin III; myosin-III; neither inactivation Nor afterpotential C; neither inactivation nor after potential C; neither inactivation nor afterpotential-C; ninaC-PA; ninaC-PB; ninaC-PC; ninaC-PD

NP_001260189.1

EC 2.7.11.1

EC 5.6.1.8

NP_001260190.1

EC 2.7.11.1

EC 5.6.1.8

NP_523503.2

EC 2.7.11.1

EC 5.6.1.8

NP_723271.1

EC 2.7.11.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

7377702..7384344

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078779.3 → NP_523503.2 neither inactivation nor afterpotential C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523503.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P10676, P10677, Q8MRP1, Q9VM23, Q9VM24

Related

FBpp0079064

Conserved Domains (4) summary

smart00220
Location:16 → 282

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00242
Location:327 → 1034

MYSc; Myosin. Large ATPases

cd06608
Location:9 → 282

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases

cd14882
Location:346 → 1022

MYSc_Myo21; class XXI myosin, motor domain
NM_001273260.1 → NP_001260189.1 neither inactivation nor afterpotential C, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260189.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCU0

Conserved Domains (4) summary

smart00220
Location:16 → 282

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00242
Location:327 → 1034

MYSc; Myosin. Large ATPases

cd06608
Location:9 → 282

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases

cd14882
Location:346 → 1022

MYSc_Myo21; class XXI myosin, motor domain
NM_164747.1 → NP_723271.1 neither inactivation nor afterpotential C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723271.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCU0

Related

FBpp0079065, FBtr0079437

Conserved Domains (4) summary

smart00220
Location:16 → 282

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00242
Location:327 → 1034

MYSc; Myosin. Large ATPases

cd06608
Location:9 → 282

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases

cd14882
Location:346 → 1022

MYSc_Myo21; class XXI myosin, motor domain
NM_001273261.1 → NP_001260190.1 neither inactivation nor afterpotential C, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260190.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCU0

Conserved Domains (4) summary

smart00220
Location:16 → 282

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00242
Location:327 → 1034

MYSc; Myosin. Large ATPases

cd06608
Location:9 → 282

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases

cd14882
Location:346 → 1022

MYSc_Myo21; class XXI myosin, motor domain