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    viaf viral IAP-associated factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39364, updated on 17-Dec-2024

    Summary

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    Official Symbol
    viafprovided by FlyBase
    Official Full Name
    viral IAP-associated factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036237
    Locus tag
    Dmel_CG18593
    See related
    AllianceGenome:FB:FBgn0036237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0134798.17; anon-WO0134798.18; CG18593; Dmel\CG18593; Viaf; VIAF; viaf1
    Summary
    Predicted to be involved in negative regulation of chaperone-mediated protein folding and protein folding. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in cytoplasm. Is expressed in dorsal pharyngeal muscle primordium; larval muscle system; organism; and somatic muscle primordium. Orthologous to several human genes including PDCL3 (phosducin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See viaf in Genome Data Viewer
    Location:
    68F1-68F1; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11991853..11993179, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11984953..11986279, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Grip163 Neighboring gene Pop2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans. Wilkinson SP, et al. J Biol Chem, 2004 Dec 3. PMID 15448166
    2. The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster. Petit C, et al. PLoS One, 2024. PMID 39480878, Free PMC Article
    3. VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. Wilkinson JC, et al. J Biol Chem, 2004 Dec 3. PMID 15371430
    4. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    5. Combining mapping and arraying: An approach to candidate gene identification. Wayne ML, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12415114, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    viral IAP-associated factor
    Names
    CG18593-PA
    viaf-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11991853..11993179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079308.2 → NP_524032.2  viral IAP-associated factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524032.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86G89, Q8MR62, Q9VTS2
      Related
      FBpp0075794, FBtr0076062
      Conserved Domains (1) summary
      cd02988
      Location:8 → 210
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR62.1 Q8MR62

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