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    caly calypso [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    calyprovided by FlyBase
    Official Full Name
    calypsoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262166
    Locus tag
    Dmel_CG8445
    See related
    AllianceGenome:FB:FBgn0262166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bap1; BAP1; Calypso; CG8445; Dmel\CG8445; Q7K5N4
    Summary
    Enables chromatin binding activity and cysteine-type deubiquitinase activity. Involved in heterochromatin formation and specification of segmental identity, abdomen. Located in chromatin and nucleus. Part of PR-DUB complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in basal cell carcinoma; extrahepatic bile duct adenocarcinoma; and uveal melanoma. Orthologous to human BAP1 (BRCA1 associated deubiquitinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See caly in Genome Data Viewer
    Location:
    52F7-52F7; 2-78 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16194062..16196333, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12081567..12083838, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lissencephaly-1 Neighboring gene uncharacterized protein Neighboring gene clueless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. Foglizzo M, et al. Nat Commun, 2018 Sep 26. PMID 30258054, Free PMC Article
    2. Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX. De I, et al. Structure, 2019 Mar 5. PMID 30639226
    3. Molecular Regulation of the Polycomb Repressive-Deubiquitinase. Reddington CJ, et al. Int J Mol Sci, 2020 Oct 22. PMID 33105797, Free PMC Article
    4. PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction. Bonnet J, et al. Genes Dev, 2022 Oct 1. PMID 36357125, Free PMC Article
    5. Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. Li T, et al. Epigenetics Chromatin, 2017 Sep 19. PMID 28927461, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, abdomen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PR-DUB complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PR-DUB complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calypso
    Names
    CG8445-PA
    CG8445-PB
    caly-PA
    caly-PB
    ubiquitin thiolesterase
    NP_611096.1
    NP_788374.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16194062..16196333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176194.2 → NP_788374.1  calypso, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K5N4
      Related
      FBpp0086384
      Conserved Domains (1) summary
      cd09617
      Location:46 → 274
      Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1

    2. NM_137252.3 → NP_611096.1  calypso, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K5N4
      Related
      FBpp0086383
      Conserved Domains (1) summary
      cd09617
      Location:46 → 274
      Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5N4.1 Q7K5N4

    Gene LinkOut

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