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    Sbds SBDS ribosome maturation factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sbdsprovided by FlyBase
    Official Full Name
    SBDS ribosome maturation factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035714
    Locus tag
    Dmel_CG8549
    See related
    AllianceGenome:FB:FBgn0035714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8549; Dmel\CG8549; dSBDS
    Summary
    Predicted to enable ribosome binding activity. Involved in cytosolic ribosome assembly. Predicted to be located in nucleolus. Is expressed in adult head. Used to study Shwachman-Diamond syndrome. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome and aplastic anemia. Orthologous to human SBDS (SBDS ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sbds in Genome Data Viewer
    Location:
    65C3-65C3; 3-17 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6752913..6754029)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6746013..6747129)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dikar Neighboring gene veloren Neighboring gene Ist1 Neighboring gene Radial spoke head protein 3 Neighboring gene long non-coding RNA:CR45759

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome. Takai A, et al. Neurosci Lett, 2020 Nov 20. PMID 33115644
    2. Somatic genetic rescue of a germline ribosome assembly defect. Tan S, et al. Nat Commun, 2021 Aug 19. PMID 34413298, Free PMC Article
    3. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Boocock GR, et al. Nat Genet, 2003 Jan. PMID 12496757
    4. Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila. Dobens LL, et al. Cancers (Basel), 2021 Feb 20. PMID 33672471, Free PMC Article
    5. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome.
      Title: A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytosolic ribosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytosolic ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SBDS ribosome maturation factor
    Names
    CG8549-PA
    CG8549-PB
    Sbds-PA
    Sbds-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6752913..6754029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139800.3 → NP_648057.2  SBDS ribosome maturation factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648057.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXD6, Q9VRY5
      Related
      FBpp0076652
      Conserved Domains (1) summary
      PTZ00448
      Location:4 → 226
      PTZ00448; hypothetical protein; Provisional

    2. NM_001274553.1 → NP_001261482.1  SBDS ribosome maturation factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXD6, Q9VRY5
      Conserved Domains (1) summary
      PTZ00448
      Location:4 → 226
      PTZ00448; hypothetical protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXD6 Q8SXD6
    Q9VRY5 Q9VRY5

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