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    Kul Kuzbanian-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kulprovided by FlyBase
    Official Full Name
    Kuzbanian-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039688
    Locus tag
    Dmel_CG1964
    See related
    AllianceGenome:FB:FBgn0039688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADAM10; CG1964; CT3146; Dmel\CG1964; kul
    Summary
    Enables metalloendopeptidase activity. Involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kul in Genome Data Viewer
    Location:
    99B9-99B9; 3-99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29725830..29735360)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25551552..25561082)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pterin-4a-carbinolamine dehydratase Neighboring gene N(alpha)-acetyltransferase 40 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Complex I intermediate-associated protein, 30 kDa Neighboring gene Glucosamine-phosphate N-acetyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-Cell-Autonomous Function of the GPI-Anchored Protein Undicht during Septate Junction Assembly. Petri J, et al. Cell Rep, 2019 Feb 5. PMID 30726744
    2. kuzbanian-mediated cleavage of Drosophila Notch. Lieber T, et al. Genes Dev, 2002 Jan 15. PMID 11799064, Free PMC Article
    3. Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease. Reinhardt S, et al. Cell Mol Life Sci, 2019 Mar. PMID 30599067, Free PMC Article
    4. E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans. Revici R, et al. Biomolecules, 2022 Jan 27. PMID 35204725, Free PMC Article
    5. IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells. Fic W, et al. Development, 2019 Jan 18. PMID 30635283, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kuzbanian-like
    Names
    ADAM10
    CG1964-PA
    CG1964-PB
    CG1964-PC
    Kul-PA
    Kul-PB
    Kul-PC
    NP_001287589.1
    NP_001287590.1
    NP_651716.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29725830..29735360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300660.1 → NP_001287589.1  Kuzbanian-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6QU66, Q9VAI2
      Conserved Domains (4) summary
      cd04270
      Location:479 → 713
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:720 → 803
      Disintegrin; Disintegrin
      pfam01562
      Location:72 → 174
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:502 → 696
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    2. NM_001300661.1 → NP_001287590.1  Kuzbanian-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHU2
      Conserved Domains (4) summary
      cd04270
      Location:479 → 713
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:720 → 803
      Disintegrin; Disintegrin
      pfam01562
      Location:72 → 174
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:502 → 696
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    3. NM_143459.3 → NP_651716.1  Kuzbanian-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6QU66, Q9VAI2
      Related
      FBpp0084826
      Conserved Domains (4) summary
      cd04270
      Location:479 → 713
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:720 → 803
      Disintegrin; Disintegrin
      pfam01562
      Location:72 → 174
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:502 → 696
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHU2 A0A0B4LHU2
    Q9VAI2 Q9VAI2

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