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    AdamTS-A ADAM metallopeptidase with thrombospondin type 1 motif A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AdamTS-Aprovided by FlyBase
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286071
    Locus tag
    Dmel_CG14869
    See related
    AllianceGenome:FB:FBgn0286071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADAMTS-A; CG14869; CG6107; CT19033; Dmel\CG14869; l(3)89Aa; rnwy
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in several processes, including epithelial cell migration, open tracheal system; larval salivary gland morphogenesis; and mesodermal cell migration. Predicted to be active in extracellular matrix. Is expressed in several structures, including embryonic/larval midgut longitudinal visceral muscle cell; embryonic/larval salivary gland; embryonic/larval visceral tracheal branch; surface glial cell; and visceral mesoderm derivative. Orthologous to several human genes including ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AdamTS-A in Genome Data Viewer
    Location:
    88F5-88F6; 3-57 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15442246..15476193, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11267968..11301915, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin 88F Neighboring gene snoRNA:Orphan H/ACA box 9 Neighboring gene B9d1 Neighboring gene Rhodopsin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Simulation and in vivo experimentation predict AdamTS-A location of function during caudal visceral mesoderm migration in Drosophila. Hamilton WC, et al. Dev Dyn, 2022 Jul. PMID 35023238
    2. AdamTS proteases control basement membrane heterogeneity and organ shape in Drosophila. Töpfer U, et al. Cell Rep, 2024 Jul 23. PMID 38944833
    3. Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. Nicholson AC, et al. BMC Evol Biol, 2005 Feb 4. PMID 15693998, Free PMC Article
    4. Nucleoporin107 mediates female sexual differentiation via Dsx. Shore T, et al. Elife, 2022 Mar 21. PMID 35311642, Free PMC Article
    5. The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Nagy V, et al. Cell Cycle, 2015. PMID 25891934, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this study, whole genome expression analysis was performed to identify genes activated by JAK/STAT and/or EGFR..AdamTS-A mRNA becomes enriched at the anterior and posterior poles of the egg chamber at stages 6 to 7 and is regulated by JAK/STAT.
      Title: A Gene Expression Screen in Drosophila melanogaster Identifies Novel JAK/STAT and EGFR Targets During Oogenesis.
    2. This work supports a model in which AdamTS-A anchors cells in place and preserves central nervous system architecture by reducing tissue stiffness.
      Title: The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.
    3. ADAMTS-A detaches salivary gland cells from the apical extracellular matrix.
      Title: The secreted AdamTS-A metalloprotease is required for collective cell migration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADAM metallopeptidase with thrombospondin type 1 motif A
    Names
    AdamTS-A-PB
    AdamTS-A-PC
    AdamTS-A-PE
    CG14869-PB
    CG14869-PC
    CG14869-PE
    lethal (3) 89Aa
    runaway
    NP_001262604.1
    NP_732036.2
    NP_996218.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15442246..15476193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206496.2 → NP_996218.1  ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXB0, Q9VF61
      Conserved Domains (7) summary
      smart00209
      Location:754 → 806
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:455 → 655
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:457 → 655
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:286 → 394
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:937 → 1042
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08685
      Location:1495 → 1687
      GON; GON domain
      pfam12115
      Location:696 → 745
      Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation

    2. NM_001275675.1 → NP_001262604.1  ADAM metallopeptidase with thrombospondin type 1 motif A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHK4
      Conserved Domains (7) summary
      smart00209
      Location:651 → 703
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:352 → 552
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:354 → 552
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:183 → 291
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:834 → 939
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08685
      Location:1392 → 1584
      GON; GON domain
      pfam12115
      Location:593 → 642
      Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation

    3. NM_169659.3 → NP_732036.2  ADAM metallopeptidase with thrombospondin type 1 motif A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732036.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSH7
      Related
      FBpp0308490
      Conserved Domains (7) summary
      smart00209
      Location:603 → 655
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:304 → 504
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:306 → 504
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:135 → 243
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:786 → 891
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08685
      Location:1344 → 1536
      GON; GON domain
      pfam12115
      Location:545 → 594
      Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHK4 A0A0B4KHK4
    Q7KSH7 Q7KSH7
    Q8SXB0 Q8SXB0

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