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    CG11598 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41554, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG11598provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038067
    Locus tag
    Dmel_CG11598
    See related
    AllianceGenome:FB:FBgn0038067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11598
    Summary
    Predicted to enable triacylglycerol lipase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in egg; female reproductive system; oviduct; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11598 in Genome Data Viewer
    Location:
    87C3-87C3; 3-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12634917..12636283)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8460639..8462005)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 10 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46018 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging. Curley M, et al. Cell Rep Methods, 2024 Oct 21. PMID 39383859, Free PMC Article
    2. BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions. Hopkins BR, et al. Proc Natl Acad Sci U S A, 2019 Dec 3. PMID 31740617, Free PMC Article
    3. High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis. Sridharan V, et al. PLoS One, 2016. PMID 26942929, Free PMC Article
    4. Candidate transcriptomic sources of inbreeding depression in Drosophila melanogaster. Garcia C, et al. PLoS One, 2013. PMID 23922905, Free PMC Article
    5. Fates and targets of male accessory gland proteins in mated female Drosophila melanogaster. Ravi Ram K, et al. Insect Biochem Mol Biol, 2005 Sep. PMID 15979005

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11598-PB
    NP_001036710.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12634917..12636283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043245.2 → NP_001036710.1  uncharacterized protein Dmel_CG11598 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI77, Q3HKQ6
      Conserved Domains (2) summary
      PLN02872
      Location:22 → 384
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:21 → 82
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI77 Q0KI77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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