mAcon2 Mitochondrial aconitase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mAcon2provided by FlyBase
Official Full Name: Mitochondrial aconitase 2provided by FlyBase
Primary source: FLYBASE:FBgn0037862
Locus tag: Dmel_CG4706
See related: AllianceGenome:FB:FBgn0037862
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4706; Dmel\CG4706; FBgn0037862
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic/larval midgut; organism; spermatozoon; and testis. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11137177..11139742)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6962899..6965464)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes.
Title: ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes.

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Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in sexual reproduction	HEP more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	HDA more info	PubMed
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_650042.2

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The following sections contain reference sequences that belong to a specific genome build. Explain